Postoperative Respiratory Depression After Cardiac Surgery
CABG PRD
Perioperative Parameters to Predict Postoperative Respiratory Depression After Cardiac Surgery
2 other identifiers
observational
44
1 country
1
Brief Summary
Coronary artery bypass graft surgery (CABG) is associated with postoperative respiratory depression. In this study we aimed at investigating perioperative parameters that could predict the nadir of postoperative respiratory function impairment.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for all trials
Started Jan 2012
Shorter than P25 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
January 1, 2012
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 1, 2012
CompletedStudy Completion
Last participant's last visit for all outcomes
November 1, 2012
CompletedFirst Submitted
Initial submission to the registry
February 26, 2014
CompletedFirst Posted
Study publicly available on registry
February 28, 2014
CompletedMarch 30, 2016
March 1, 2016
5 months
February 26, 2014
March 29, 2016
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Postoperative Respiratory Depression After Cardiac Surgery
Respiratory function is assessed through maximal inspiratory (MIP) and expiratory (MEP) pressures and peak expiratory flow (PEF) determined 1 day before surgery and one postoperative week.
9 days
Secondary Outcomes (2)
Intraoperative parameters after coronary artery bypass graft surgery (CABG)
1 day
Perioperative parameters after coronary artery bypass graft surgery (CABG)
3 days
Eligibility Criteria
Patients with coronary artery disease submitted to elective CABG with CPB.
You may qualify if:
- patients of both sexes older than 18 years submitted to CABG with CPB, presence of coronary disease confirmed by coronary angiography, use of the left internal thoracic artery and/or saphena, patients who remained in spontaneous ventilation on the first postoperative day, absence of chronic or acute pulmonary disease, and giving written informed consent to participate in the study.
You may not qualify if:
- intraoperative change of the surgical technique, surgical complications or complications occurring in the ICU, emergency reoperation, renal failure, failure to agree to continue in the study, presence of other types of heart disease, and presence of pulmonary diseases.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Hospital Sao Marcos
Teresina, Piauí, 64001-280, Brazil
Related Publications (1)
Costa AS, Costa PH, de Lima CE, Padua LE, Campos LA, Baltatu OC. ICU Blood Pressure Variability May Predict Nadir of Respiratory Depression After Coronary Artery Bypass Surgery. Front Neurosci. 2016 Jan 11;9:506. doi: 10.3389/fnins.2015.00506. eCollection 2015.
PMID: 26903799DERIVED
Related Links
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY CHAIR
Ovidiu C Baltatu, MD PhD
Camilo Castelo Branco University (UNICASTELO)
Study Design
- Study Type
- observational
- Observational Model
- CASE CROSSOVER
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR INVESTIGATOR
- PI Title
- Professor
Study Record Dates
First Submitted
February 26, 2014
First Posted
February 28, 2014
Study Start
January 1, 2012
Primary Completion
June 1, 2012
Study Completion
November 1, 2012
Last Updated
March 30, 2016
Record last verified: 2016-03