Contribution of the Cerebellum In Sensory-motor Adaptation Via Gamma Oscillations: the Case of Dystonia

NCT02073630 | Completed

• 1 other identifier: C13-45
• Study Type: interventional
• Target: 63
• Locations: 1 country
• Sites: 1

Brief Summary

Dystonia, a disabling disease with uncontrolled movement disorders was considered to be a manifestation of basal ganglia dysfunction, yet there is accumulating evidence from animal and human experiments that the cerebellum plays a prominent role in the pathophysiology of dystonia. Our recent results suggest a deficient cerebellar sensory encoding in dystonia, resulting in a decoupling of the motor component from the afferent information flow resulting from changes in the environment. An overall loss of gabaergic-mediated inhibition is at the forefront in dynamic changes in neural circuitry described in dystonia. In the mature brain gabaergic control the generation of temporal synchronies and oscillations in the glutamatergic neurons. Taken these all together with the results of a pilot experiment, the investigators hypothesize that deficient synchronies in the fast gamma range are one of the key mechanisms leading to abnormal communication inside the cerebello-cortical network in dystonia. The investigators aim first to demonstrate it by means of MEG (Magneto encepholography) recordings allowing to reconstruct the spatio-temporal dynamics of gamma oscillations in the nodes of the cerebello-cortical network. The investigators then aim to re-establish (if lost) or boost (if decreased) the defective synchronies by applying to the cerebellum at high gamma frequency a non invasive transcranial alternative current stimulation.

Conditions

Primary Dystonia

Keywords

magnetoencephalography; non invasive brain stimulation; cerebellum; gamma rhythms

Outcome Measures

Primary Outcomes (1)

• change in gamma oscillations power in the cerebellum during a sensorimotor adaptation task

  MEG recording will be performed using a whole-head 306-channels MEG system (Elekta Neuromag® TriuxTM System) comprising 204 planar gradiometers and 102 magnetometers regularly distributed at 102 locations over the scalp. MEG data will be coregistered with the structural MRI of each subject using BrainStorm (http://neuroimage.usc.edu/brainstorm). The localization of the source will be constrained with the individual anatomy obtained with MRI.

  measures will be done at each of 3 visits: visit1, visit2 at expected average 7 days after visit1 and visit3 at expected average 14 days after visit1

Secondary Outcomes (1)

• synchrony in the gamma band between the cerebellum and the sensorimotor cortex

  measures will be done at each of 3 visits: visit1, visit2 at expected average 7 days after visit1 and visit3 at expected average 14 days after visit1

Other Outcomes (1)

• behavioral performances at a sensorimotor adaptation task

  measures will be done at each of 3 visits: visit1, visit2 at expected average 7 days after visit1 and visit3 at expected average 14 days after visit1

Study Arms (2)

Healthy subjects

OTHER

healthy subjects will receive either sham or active cerebellar stimulation

Other: active cerebellar stimulation; Other: sham cerebellar stimulation

Dystonia

OTHER

dystonic patients will receive either sham or active cerebellar stimulation

Other: active cerebellar stimulation; Other: sham cerebellar stimulation

Interventions

active cerebellar stimulation OTHER

Dystonia; Healthy subjects

sham cerebellar stimulation OTHER

Dystonia; Healthy subjects

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• primary upper limb dystonia
• normal physical and neurological examination except for dystonia
• no treatment with botulinum toxin during the three months preceding the study

You may not qualify if:

• Writing tremor
• current neurological or psychiatric illness other than dystonia
• uncontrollable medical problems not related to dystonia
• pregnancy, breast feeding women and women who are of childbearing age and not practicing adequate birth control

Sponsors & Collaborators

• Institut National de la Santé Et de la Recherche Médicale, France: lead

Study Sites (1)

ICM GH Pitié Salpetrière

Paris, 75651, France

Location

MeSH Terms

Conditions

Dystonic Disorders

Condition Hierarchy (Ancestors)

Movement Disorders; Central Nervous System Diseases; Nervous System Diseases

Study Officials

• sabine meunier, MD, PhD

  Institut National de la Santé Et de la Recherche Médicale, France

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER GOV
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 19, 2014
• First Posted: February 27, 2014
• Study Start: February 1, 2014
• Primary Completion: February 1, 2016
• Study Completion: August 1, 2016
• Last Updated: November 6, 2017

Record last verified: 2016-08

Locations

FR (1)