Muscle Blood Flow During Exercise

NCT02070848 | Completed

• 1 other identifier: 5456
• Study Type: observational
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

Physical exercise triggers various physiological responses including a marked increase in muscle blood flow and oxygen delivery in order to support muscle activity. How muscle blood flow is controlled is currently unclear. The primary purpose of this study is to establish the respective contribution of metabolic (linked to energy requirements) and mechanical (linked to muscle tensions) signals in the exercise hyperemia and the possible role of the red blood cells. Vasodilation and muscle blood flow during exercise are controlled by ATP released in the plasma from the red blood cells in response to a combination of metabolic and mechanical signals applied on the vasculature.

Conditions

Skeletal Muscle Blood Flow

Keywords

red blood cell; knee extension exercise

Outcome Measures

Primary Outcomes (1)

• Change in leg blood flow during concentric and eccentric muscle work

  Serial measures (9) of leg blood flow during concentric and eccentric muscle work are performed at the beginning of the exercise (t0), and then after 14 minutes (t14), after 18 minutes (t18), after 22 minutes (t22), after 26 minutes (t26), after 30 minutes (t30), after 33 minutes (t33), after 35 minutes (t35), and after 45 minutes (45) during each exercice, concentric and eccentric.

  Leg blood flow measurements during exercises performed at the beginning, after 14 minutes, then after 18 min, 22 min, 26 min, 30 min, 33 min, 35 min and 45 min

Study Arms (1)

Concentric vs eccentric

One arm study in which each subject will act as his own control.

Other: Session 1-4; Other: Session 4; Other: Session 5

Interventions

Session 1-4 OTHER

Familiarization sessions to knee-extensor exercise separated by 72h recovery

Concentric vs eccentric

Session 4 OTHER

After the last familiarization session, 1 maximal incremental test on a bicycle, followed by 72h rest

Concentric vs eccentric

Session 5 OTHER

2 maximal incremental tests of knee-extension exercise (concentric vs eccentric), separated by 3h rest.

Concentric vs eccentric

Eligibility Criteria

• Age: 18 Years - 45 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Subjects will be students recruited in the Faculty, sports clubs...

You may qualify if:

• Non smoker or having stopped smoking for at least 5 yr
• Practice sports: physical activity level will be evaluated with a questionnaire (de Baecke et coll., 1982) and will give an activity index greater than 6 together with a VO2max greater than 50 ml/kg/min
• Body mass index lower than 25
• Registered to the French Social Security system
• Providing a written and informed consent to participate in the study

You may not qualify if:

• History of venous or arterial thrombo-embolic events
• Bad perfusion from the cubital artery
• Unable to understand the information notice
• Subject exposed to law investigations or with financial dependancy
• Subjects feeling unwell whan seing blood.
• Subjects advised to not practice sport.
• Musculo-tendinous or articular issues with the lower leg
• Respiratory, cardiovascular or metabolic pathologies
• Current medical treatment that can not be stopped 7 days before the experiment.

Sponsors & Collaborators

• University Hospital, Strasbourg, France: lead

Study Sites (1)

SERVICE DE PHYSIOLOGIE ET D'EXPLORATIONS FONCTIONNELLES - Nouvel Hôpital Civil

Strasbourg, 67091, France

Location

Study Officials

• Stéphane DOUTRELEAU, MD

  Hôpitaux Universitaires de Strasbourg

  PRINCIPAL INVESTIGATOR

• DUFOUR Stéphane, MD

  Faculté des Sciences du Sport 14 Rue René Descartes 67084 Strasbourg

  STUDY DIRECTOR

• FAVRET Fabrice, MD

  Faculté des Sciences du Sport 14 Rue René Descartes 67084 Strasbourg

  STUDY CHAIR

• LONSDORFER Evelyne, MD

  Hôpitaux Universitaires de Strasbourg

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 14, 2014
• First Posted: February 25, 2014
• Study Start: September 1, 2018
• Primary Completion: October 19, 2018
• Study Completion: October 19, 2018
• Last Updated: March 5, 2021

Record last verified: 2021-03

Locations

FR (1)