Working Memory Training in Adults With Substance Abuse and Executive Function Deficits.

NCT02068261 | Unknown Phase 2

• 1 other identifier: RA02
• Study Type: interventional
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to evaluate the effects of a computerized working memory training program on substance abuse, psychosocial functioning, cognitive performance and psychiatric problems in adults with substance abuse and attention problems.

Conditions

Substance Abuse; Executive Dysfunction; Anxiety; Depression; Antisocial Personality; Reading Disabilities

Outcome Measures

Primary Outcomes (1)

• Change from baseline in substance abuse measured with Substance abuse scales in Adult Self Report (ASR; ASEBA).

  Baseline and at 25 weeks

Secondary Outcomes (10)

• Change from baseline in Adult Self Report (ASR; ASEBA) Attention problems scale.

  Baseline and at 25 weeks

• Change from baseline in Adult Self Report (ASR; ASEBA) Internalizing index.

  Baseline and at 25 weeks

• Change from baseline in Adult Self Report (ASR; ASEBA) Externalizing index.

  Baseline and at 25 weeks

• Change from baseline in Adult Self Report (ASR; ASEBA) Adaptive functioning scales.

  Baseline and at 25 weeks

• Change from baseline in Executive functioning measured with Behavior Rating Inventory of Executive Function-Adult (BRIEF-A).

  Baseline and at 25 weeks

Study Arms (2)

Cogmed working memory training

EXPERIMENTAL

30-40 minutes of Cogmed computerized working memory training 3-5 days a week for 5-8 weeks. Every training session consists of a set of visual- and verbal working memory tasks that are trained on during the session.

Behavioral: Computerized Cogmed working memory training

Treatment as usual

ACTIVE COMPARATOR

Treatment as usual can consist of medication, psychotherapy, counseling, and psychological assessment. After a 8 week period participants in this arm well be offered Cogmed working memory training.

Behavioral: Treatment as usual

Interventions

Computerized Cogmed working memory training BEHAVIORAL

Computerized working memory training with Cogmed QM software. The QM software consists of a set of verbal and visual working memory tasks which is trained for 25-40 minutes each session.

Cogmed working memory training

Treatment as usual BEHAVIORAL

Treatment as usual can consist of medication, psychotherapy, counseling, and psychological assessment.

Treatment as usual

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Treatment seeking adults with substance abuse and executive function deficits.

You may not qualify if:

• Acute intoxication or abstinence symptoms of any substance.
• Psychosis.

Sponsors & Collaborators

• Örebro Läns Landsting: lead

Study Sites (1)

Psychiatric Research Centre

Örebro, Örebro County, 701 16, Sweden

RECRUITING

MeSH Terms

Conditions

Substance-Related Disorders; Anxiety Disorders; Depression; Antisocial Personality Disorder; Dyslexia

Interventions

Therapeutics

Condition Hierarchy (Ancestors)

Chemically-Induced Disorders; Mental Disorders; Behavioral Symptoms; Behavior; Personality Disorders; Language Disorders; Communication Disorders; Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Specific Learning Disorder; Learning Disabilities; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Neurodevelopmental Disorders

Study Officials

• Lars Kjellin, Docent

  Örebro Läns Landsting

  STUDY DIRECTOR

Central Study Contacts

Rickard Ahlberg, doctoral student

CONTACT

rickard.ahlberg@orebroll.se

Kurt Skårberg, MD

CONTACT

kurt.skarberg@orebroll.se

Study Design

• Study Type: interventional
• Phase: phase 2
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Clinical psychologist, doctoral student.

Study Record Dates

• First Submitted: February 19, 2014
• First Posted: February 21, 2014
• Study Start: January 1, 2014
• Primary Completion: December 1, 2016
• Study Completion: December 1, 2016
• Last Updated: October 23, 2015

Record last verified: 2015-10

Locations

SE (1)