European Dyspnoea Survey in the EMergency Departments

NCT02060799 | Completed DMC

• 1 other identifier: HLariboisiere
• Study Type: observational
• Target: 2,156
• Locations: 10 countries
• Sites: 10

Brief Summary

Braunwald defines dyspnoea as an abnormally uncomfortable awareness of breathing. Breathing discomfort, and its varying degrees of severity, is the one of the most disturbing symptoms patients can experience; and it is one of the main complaints in the patients presenting to the Emergency Department (ED). Dyspnea has a variety of underlying etiologies, like cardiac, pulmonary or metabolic etiologies or a combination of them, since several diseases can cause dyspnea like for instance heart failure (HF), asthma and chronic obstructive pulmonary disease (COPD). Acute heart failure syndrome (AHFS) is collectively defined as a gradual or rapid change in heart failure (HF) signs and symptoms resulting in a need for urgent therapy. Heart failure (HF) is one of the most important causes of morbidity and mortality in the industrialized world. The prevalence of symptomatic HF is estimated to range from 0.4 to 2.0% in general European population. The incidence increases rapidly with age, and in Europe. Characteristics, clinical presentation, treatment, and outcomes of HF patients admitted to hospital have been adequately described, in Europe and in the United States. The Euro Heart Failure Survey (EHFS) I with 11 327 patients described the demographics of acutely hospitalized HF patients. The ADHERE registry has data on over 100 000 hospitalizations for AHF from the USA. In-hospital mortality was 4 and 7%, in ADHERE and EHFS I, respectively. This same sensation of breathlessness is what also drives patients with asthma and chronic obstructive pulmonary disease (COPD) to the ED. Chronic obstructive pulmonary disease (COPD) exacerbation accounts for approximately 1.5 million ED visits in the United States per year. It is the third most common cause of hospitalization, with an estimated 726 000 hospitalizations in 2000 in the USA. Previous studies have demonstrated important differences between guideline recommendations and actual management of COPD exacerbation, either in the ED or during hospitalization. The diagnosis in front of a dyspneic patient in the ED remains a challenge, because of a low sensitivity of the clinical signs associated with the aging of the population and the variety of underlying diseases. Little is known about the Epidemiology of dyspneic patients in the ED at the European level. Diagnosis, prevalence and treatment of the patients may vary among European countries.

Conditions

Dyspnea; Emergencies

Keywords

Dyspnea; Emergency Service, Hospital; prognosis; Fatal Outcome; Epidemiology

Outcome Measures

Primary Outcomes (1)

• All cause mortality

  All cause mortality will be evaluated 30 days after ED visit.

  30 days

Secondary Outcomes (1)

• All cause rehospitalization

  30 days

Other Outcomes (1)

• ED visit

  30 days

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Consecutive patients presenting to the Emergency Department with Dyspnea as main complaint during the study period.

You may qualify if:

• Consecutive patients presenting to the Emergency Department with Dyspnea as main complaint
• years or older

You may not qualify if:

• No acceptance to participate from the patient

Sponsors & Collaborators

• Hopital Lariboisière: lead

Study Sites (10)

Country: Belgium

Brussels, Belgium

Location

Country: Finland

Helsinki, Finland

Location

Country: France

Paris, France

Location

Country: Germany

Nuremberg, Germany

Location

Country: Italy

Rome, Italy

Location

Country: Netherlands

Amsterdam, Netherlands

Location

Country: Romania

Cluj-Napoca, Romania

Location

Country: Spain

Santander, Spain

Location

Country: Turkey

Ankara, Turkey (Türkiye)

Location

Country: United Kingdom

Manchester, United Kingdom

Location

MeSH Terms

Conditions

Dyspnea; Emergencies

Condition Hierarchy (Ancestors)

Respiration Disorders; Respiratory Tract Diseases; Signs and Symptoms, Respiratory; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Disease Attributes; Pathologic Processes

Study Officials

• Said LARIBI, MD, PhD

  Lariboisière Hospital, EuSEM

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 30 Days
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: February 9, 2014
• First Posted: February 12, 2014
• Study Start: February 1, 2014
• Primary Completion: March 1, 2014
• Study Completion: November 1, 2014
• Last Updated: December 18, 2014

Record last verified: 2014-12

Locations

TU (1); IT (1); RO (1); FI (1); ES (1); GB (1); BE (1); DE (1); FR (1); NL (1)