Daily Activity After Corticosteroids Injection Among Knee Osteoarthritis Patients

NCT02049879 | Completed Phase 4

• 1 other identifier: INF-2010
• Study Type: interventional
• Target: 14
• Locations: 1 country
• Sites: 1

Brief Summary

The objective of this study was to objectively measure daily physical activity and spatiotemporal gait pattern, as well as improvements in self reported symptoms and quality of life, before and six weeks after an intra-articular corticosteroids injection in patients suffering from knee osteoarthritis. Fourteen patients with unilateral knee osteoarthritis were recruited. The intra-articular corticosteroid injection was given at the end of the second week. Physical activity was objectively measured by an accelerometer worn by the participants for eight weeks. In addition, the Western Ontario and McMaster Universities Arthritis Index (WOMAC), the Medical Outcome Study Short Form-36 (MOS-SF36) and gait trials were completed every two weeks to assess symptoms, quality of life and spatiotemporal parameters of gait.

Conditions

Knee Osteoarthritis

Outcome Measures

Primary Outcomes (2)

• Change in Knee pain

  Change from Baseline at 2, 4 and 6 weeks

• Change in physical activity

  Change from baseline at 2, 4 and 6 weeks

Secondary Outcomes (2)

• Change in function and quality of life

  Change from baseline at 2, 4 and 6 weeks

• Change in Spatiotemporal gait parameters

  Change from Baseline at 2, 4 and 6 weeks

Study Arms (1)

Injection

EXPERIMENTAL

Corticosteroids injection

Drug: Corticosteroids injection

Interventions

Corticosteroids injection DRUG

A solution of triamcinolone 40 mg (Kenalog) mixed with 3 cc of 2% xylocaine without epinephrine.

Injection

Eligibility Criteria

• Age: 50 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• years old or more
• Medial knee osteoarthritis (Kellgren \& Lawrence Grade I to III)

You may not qualify if:

• Intra-articular injection during the last six months
• Isolated femoro-patellar arthritis
• Rheumatoid arthritis
• Knee instability
• Spinal stenosis
• Lower limb fracture over the last year
• Lower limb surgery in the last three months

Sponsors & Collaborators

• Laval University: lead

Study Sites (1)

Pavillon de l'Éducation Physique et des Sports - Université Laval

Québec, Quebec, G1V 0A6, Canada

Location

Related Publications (1)

• Dessery Y, Belzile EL, Turmel S, Dore J, Diallo B, Corbeil P. Modulation of physical activity to optimize pain sensation following an intra-articular corticosteroid injection in patients with knee osteoarthritis. ScientificWorldJournal. 2014;2014:209165. doi: 10.1155/2014/209165. Epub 2014 Nov 16.

  PMID: 25478585 DERIVED

MeSH Terms

Conditions

Osteoarthritis, Knee

Interventions

Adrenal Cortex Hormones

Condition Hierarchy (Ancestors)

Osteoarthritis; Arthritis; Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases

Intervention Hierarchy (Ancestors)

Hormones; Hormones, Hormone Substitutes, and Hormone Antagonists

Study Officials

• Philippe Corbeil, PhD

  Laval University

  STUDY DIRECTOR

• Yoann Dessery, MSc

  Laval University

  PRINCIPAL INVESTIGATOR

• Étienne Belzile, MD

  Laval University

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: phase 4
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: January 28, 2014
• First Posted: January 30, 2014
• Study Start: November 1, 2008
• Primary Completion: August 1, 2012
• Study Completion: August 1, 2012
• Last Updated: March 3, 2014

Record last verified: 2014-02

Locations

CA (1)