The Suitability of Sniff Dog as a Tool in Screening Tumors

NCT02049645 | Recruiting DMC

• 1 other identifier: Xiang-Ya 0001
• Study Type: observational
• Target: 4,000
• Locations: 1 country
• Sites: 1

Brief Summary

Previous studies have demonstrated that sniff dogs can identify cancer patients from healthy subjects through sniffing exhaled breath air or blood or serum or urine or feces. It is hypothesized that sniff dogs may be used as a tool in screening cancer patients in health examination. Trained dogs will sniff serum from participants who are attending the annual health examination to identify potential or high risk subjects, and the results will be compared with the outcome of the traditional health examination, and the high risk subjects will be followed periodically for at least five years.

Conditions

Neoplasia

Keywords

lung cancer; breast cancer

Outcome Measures

Primary Outcomes (1)

• Sensitivity and specificity in screening cancer patients

  The results that obtained from the dogs will be compared with these of the pathological examinations. Sensitivity = the No. of patients identified by the dogs as cancers / the No. of patients suffering from cancer confirmed by pathological examination. Specificity = No. of subjects signaled by the dog as non-cancers / No. of subjects confirmed by pathological examination or the currently used methods as non-cancer subjects or at the end of the study, 5 years later still without cancer.

  up to 5 years

Secondary Outcomes (1)

• Behavior patterns of sniff dogs to different diseases

  up to 5 years

Other Outcomes (1)

• The substances used by the sniff dogs to identifying tumors

  up to 5 years

Study Arms (1)

faculty staff and their adult family members

faculties and their adult family members of the Third Xiang-Ya Hospital

Eligibility Criteria

• Age: 20 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The Third Xiang-Ya Hospital staff members and their adult family members who wish to participate the study.

You may qualify if:

• old than 20 years
• currently without cancer diagnosed with pathological examination
• allow the study team to examine his/her case history and incoming record

You may not qualify if:

• cancer patients with pathological diagnosis
• who does not allow the study team to examine his/her case history and incoming record

Sponsors & Collaborators

• Chang-Qing Gao: lead

Study Sites (1)

The Third Xiang-Ya Hospital

Changsha, Hunan, 410013, China

RECRUITING

Related Publications (5)

• Ehmann R, Boedeker E, Friedrich U, Sagert J, Dippon J, Friedel G, Walles T. Canine scent detection in the diagnosis of lung cancer: revisiting a puzzling phenomenon. Eur Respir J. 2012 Mar;39(3):669-76. doi: 10.1183/09031936.00051711. Epub 2011 Aug 18.

  PMID: 21852337 BACKGROUND

• Church J, Williams H. Another sniffer dog for the clinic? Lancet. 2001 Sep 15;358(9285):930. doi: 10.1016/S0140-6736(01)06065-2. No abstract available.

  PMID: 11575380 BACKGROUND

• Willis CM, Church SM, Guest CM, Cook WA, McCarthy N, Bransbury AJ, Church MR, Church JC. Olfactory detection of human bladder cancer by dogs: proof of principle study. BMJ. 2004 Sep 25;329(7468):712. doi: 10.1136/bmj.329.7468.712.

  PMID: 15388612 BACKGROUND

• McCulloch M, Jezierski T, Broffman M, Hubbard A, Turner K, Janecki T. Diagnostic accuracy of canine scent detection in early- and late-stage lung and breast cancers. Integr Cancer Ther. 2006 Mar;5(1):30-9. doi: 10.1177/1534735405285096.

  PMID: 16484712 BACKGROUND

• Horvath G, Jarverud GA, Jarverud S, Horvath I. Human ovarian carcinomas detected by specific odor. Integr Cancer Ther. 2008 Jun;7(2):76-80. doi: 10.1177/1534735408319058. Epub 2008 May 27.

  PMID: 18505901 BACKGROUND

Biospecimen

Retention: SAMPLES WITHOUT DNA

serum

MeSH Terms

Conditions

Neoplasms; Lung Neoplasms; Breast Neoplasms

Condition Hierarchy (Ancestors)

Respiratory Tract Neoplasms; Thoracic Neoplasms; Neoplasms by Site; Lung Diseases; Respiratory Tract Diseases; Breast Diseases; Skin Diseases; Skin and Connective Tissue Diseases

Study Officials

• Chang-Qing Gao, MD PhD

  Central South University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Chang-Qing Gao, MD PhD

CONTACT

86 13974981039; cgao851@126.com

Ya-Qin Wang, MD PhD

CONTACT

86 15274810930; wdove.bb@163.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: MD PhD

Study Record Dates

• First Submitted: January 25, 2014
• First Posted: January 30, 2014
• Study Start: January 1, 2014
• Primary Completion: December 31, 2024
• Study Completion: March 1, 2026
• Last Updated: February 8, 2024

Record last verified: 2024-02

Locations

CN (1)