Optimization of MRI for Radiation Therapy

NCT02045381 | Completed DMC

• 2 other identifiers: UMCC 2012.113HUM00068061
• Study Type: observational
• Target: 250
• Locations: 1 country
• Sites: 1

Brief Summary

Currently, appropriate patients undergo MRI imaging with immobilization and sequences optimized for diagnostic radiology purposes. Using a mutual information algorithm, these images are then registered to a treatment planning CT obtained with custom immobilization to minimize intra-and inter-treatment motion and positional variation. This image registration process is time-consuming and introduces additional layers of geometric uncertainty into what should be a highly precise treatment planning process. However, it is necessary, since radiation dose calculations cannot be performed on MRI data due to the lack of crucial density information. The investigator envisions CT-less treatment planning, using only MRI, due to superior imaging characteristics, fully integrated into the radiation oncology clinic. This study will begin this process.

Conditions

Cancer Liver; Cancer Brain; Cancer Head &Neck; Cancer Pelvis

Keywords

Cancer; MRI

Outcome Measures

Primary Outcomes (1)

• Percentage of participants with MRI images suitable for analyses

  Patients will be off protocol immediately after the single MRI scan. Comparative treatment planning will occur off-line and will not be used for patient care.

  Day One

Study Arms (1)

MRI group

Patient receives one research MRI prior to radiation treatment.

Procedure: MRI Group

Interventions

MRI Group PROCEDURE

A single research MRI

MRI group

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Participants having a working diagnosis of malignancy in the liver, brain, head and neck, or pelvis, and a plan to treat with radiotherapy.

You may qualify if:

• Patients ≥18 years of age
• A working diagnosis of malignancy in the liver, brain, H\&N, or pelvis
• A plan to treat with radiotherapy

You may not qualify if:

• Patients with contraindications to having a contrast enhanced MRI scan. These contraindications will be assessed at the time of enrollment using the guidelines set up and in clinical use by the Radiology Department.

Sponsors & Collaborators

• University of Michigan Rogel Cancer Center: lead

Study Sites (1)

Univeristy of Michigan

Ann Arbor, Michigan, 48109, United States

Location

MeSH Terms

Conditions

Carcinoma, Hepatocellular; Brain Neoplasms; Head and Neck Neoplasms; Pelvic Neoplasms; Neoplasms

Condition Hierarchy (Ancestors)

Adenocarcinoma; Carcinoma; Neoplasms, Glandular and Epithelial; Neoplasms by Histologic Type; Liver Neoplasms; Digestive System Neoplasms; Neoplasms by Site; Digestive System Diseases; Liver Diseases; Central Nervous System Neoplasms; Nervous System Neoplasms; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases

Study Officials

• Shruti Jolly, MD

  University of Michigan

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 18, 2013
• First Posted: January 24, 2014
• Study Start: March 14, 2013
• Primary Completion: February 9, 2023
• Study Completion: February 9, 2023
• Last Updated: January 14, 2025

Record last verified: 2025-01

Locations

US (1)