Secretory Azoospermia and FDG (Fluoro Deoxyglucose) PET-CT
AzoPredHisto
Comparison of FDG PET-CT Estimated Testis Functional Value Between Patients Having Positive Testicular Sperm Cells Extraction and Patients With a Negative Extraction, in Men With Azoospermia
2 other identifiers
interventional
160
1 country
5
Brief Summary
Compare FDG PET-CT parameters between azoospermia patients having an extraction of sperm cells by positive testicular extraction and those with a negative extraction.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable
Started Jan 2014
Longer than P75 for not_applicable
5 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
December 13, 2013
CompletedStudy Start
First participant enrolled
January 1, 2014
CompletedFirst Posted
Study publicly available on registry
January 23, 2014
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 1, 2019
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2019
CompletedJanuary 6, 2026
November 1, 2020
5.4 years
December 13, 2013
January 2, 2026
Conditions
Outcome Measures
Primary Outcomes (1)
measure of standardized uptake value (SUV)
1 month
Secondary Outcomes (1)
comparison between functional volume with PET exam and volume obtained by scrotal echography
1 month
Other Outcomes (1)
comparison functional volume with FSH and inhibin
1 month
Study Arms (3)
secretory azoospermia
EXPERIMENTAL110 men with secretory azoospermia will have FDG PET-CT
excretory azoospermia
ACTIVE COMPARATOR30 men with secretory azoospermia will have FDG PET-CT
normospermia
PLACEBO COMPARATOR20 men with secretory azoospermia will have FDG PET-CT
Interventions
Eligibility Criteria
You may qualify if:
- absence of sperm cells on 2 spermograms in 3 months interval testicular size has to be determined in order to categorized in a group to accept surgery-
You may not qualify if:
- allergy to fluoro deoxyglucose clinical varicocele
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (5)
UHBordeaux
Bordeaux, 33076, France
University Hospital
Lille, 59037, France
Centre européen Georges Pompidou
Paris, 75015, France
University Hospital
Rouen, 76031, France
UHToulouse
Toulouse, 31059, France
Related Publications (2)
Ferretti L, Sargos P, Gross-Goupil M, Izard V, Wallerand H, Huyghe E, Rigot JM, Durand X, Benoit G, Ferriere JM, Droupy S. Testicular-sparing surgery for bilateral or monorchide testicular tumours: a multicenter study of long-term oncological and functional results. BJU Int. 2014 Dec;114(6):860-4. doi: 10.1111/bju.12549. Epub 2014 Aug 16.
PMID: 24180380BACKGROUNDDierickx LO, Bettiol C, Huglo D, Marcelli F, Sibert L, Gouel P, Ferretti L, Orlhac F, Huyghe E. Is 18F-fluorodexyglucose testicular uptake using positron emission tomography/computed tomography correlated with the results of a testicular sperm extraction procedure in the case of azoospermia (French prospective multicenter AZOPREDHISTOTEP study)? Eur J Nucl Med Mol Imaging. 2026 Apr;53(5):3283-3290. doi: 10.1007/s00259-025-07583-7. Epub 2025 Nov 21.
PMID: 41269291RESULT
Study Officials
- PRINCIPAL INVESTIGATOR
Eric HUYGHE, MD
University Hospital, Toulouse
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NON RANDOMIZED
- Masking
- NONE
- Purpose
- OTHER
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
December 13, 2013
First Posted
January 23, 2014
Study Start
January 1, 2014
Primary Completion
June 1, 2019
Study Completion
December 1, 2019
Last Updated
January 6, 2026
Record last verified: 2020-11