Contraceptive Use and Respiratory Conditions Among Scottish Women

NCT02039102 | Completed

• 1 other identifier: 75764
• Study Type: observational
• Target: 3,257
• Locations: 1 country
• Sites: 1

Brief Summary

Studies examining the sex differences in the epidemiology and morbidity patterns of asthma show that the rates of disease severity, healthcare utilisation, and poor quality of life are considerably higher in women than in men, and this has been attributed to endogenous and exogenous sex hormonal factors. Studies examining the impact of use of hormonal contraceptives on the risk of asthma and asthma-related conditions are few, yet findings are conflicting. In the present study, the investigators utilize data from the Scottish Health Survey, a national representative sample, to investigate the associations between current use of hormonal contraceptives and the prevalence of self-reported doctor-diagnosed current asthma and wheezing symptoms in Scottish women. The investigators hypothesize that while current use of any hormonal contraceptives and combined oral pills are associated with higher prevalence of asthma and asthma outcomes, current use of progesterone-only contraceptives is not associated with asthma. A secondary aim of the current study is to examine whether there is evidence of any biological interaction between use of hormonal contraceptives and BMI in relation to the risk of asthma and asthma outcomes.

Conditions

Asthma

Keywords

hormonal contraceptives; combined pills; progesterone-only contraceptives; body mass index; asthma; Scotland; women

Outcome Measures

Primary Outcomes (1)

• Self-reported doctor-diagnosed current asthma

  During the past 12 months

Secondary Outcomes (2)

• Self-reported wheezing symptom

  During the past 12 months

• Self-reported current treatment for asthma/wheeze

  During the past 12 months

Study Arms (2)

Non-users of hormonal contraceptives

Users of hormonal contraceptives

Eligibility Criteria

• Age: 16 Years - 45 Years
• Sex: female
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Probability Sample

Study Population

Non-pregnant women aged 16-45 years

You may qualify if:

• Non-pregnant
• Woman
• years old

You may not qualify if:

• Pregnant
• Man
• Younger than 16 years or older than 45 years old

Sponsors & Collaborators

• University of Edinburgh: lead

Study Sites (1)

University of Ediburgh

Edinburgh, United Kingdom

Location

Related Publications (3)

• Macsali F, Real FG, Omenaas ER, Bjorge L, Janson C, Franklin K, Svanes C. Oral contraception, body mass index, and asthma: a cross-sectional Nordic-Baltic population survey. J Allergy Clin Immunol. 2009 Feb;123(2):391-7. doi: 10.1016/j.jaci.2008.10.041. Epub 2009 Jan 3.

  PMID: 19121863 BACKGROUND

• Lange P, Parner J, Prescott E, Ulrik CS, Vestbo J. Exogenous female sex steroid hormones and risk of asthma and asthma-like symptoms: a cross sectional study of the general population. Thorax. 2001 Aug;56(8):613-6. doi: 10.1136/thorax.56.8.613.

  PMID: 11462063 BACKGROUND

• Salam MT, Wenten M, Gilliland FD. Endogenous and exogenous sex steroid hormones and asthma and wheeze in young women. J Allergy Clin Immunol. 2006 May;117(5):1001-7. doi: 10.1016/j.jaci.2006.02.004.

  PMID: 16675325 BACKGROUND

MeSH Terms

Conditions

Asthma

Condition Hierarchy (Ancestors)

Bronchial Diseases; Respiratory Tract Diseases; Lung Diseases, Obstructive; Lung Diseases; Respiratory Hypersensitivity; Hypersensitivity, Immediate; Hypersensitivity; Immune System Diseases

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 15, 2014
• First Posted: January 17, 2014
• Study Start: December 1, 2013
• Primary Completion: September 1, 2018
• Study Completion: September 1, 2018
• Last Updated: June 21, 2021

Record last verified: 2021-06

Locations

GB (1)