The Effects of Auditory Cueing on Rhythmic Movement and Cortical Excitability in Patients With Parkinson's Disease

NCT02037451 | Unknown DMC

• 1 other identifier: 102-3809A3
• Study Type: interventional
• Target: 38
• Locations: 1 country
• Sites: 1

Brief Summary

Parkinson's disease (PD) is a progressive degenerative disease of central nervous systems deficit. The clinical symptoms of Parkinson's disease include the following motor tasks: difficult in initiating movement, performing rhythmic movement or serial movement, the ability of learning motor movement is also affected. The primary treatment for Parkinson's disease is medical treatment; surgery is used if in need. Rehabilitation such as physical therapy, which aims to improve patient's quality of life and functions, is a non-invasive treatment and value for PD patients. Auditory cue is a technique that widely applied on training patients with Parkinson's disease, and some researches revealed that auditory cueing could improve motor performance. However, the mechanism under this treatment technique is still unknown. This study is to investigate the effect of auditory cueing on rhythmic finger movement in patients with Parkinson's disease. To investigate the mechanism under auditory cueing, neurophysiological data such as motor cortex excitability and blood flow in cortical cortex will be obtained by using Transcranial magnetic stimulation (TMS) and near infrared spectroscopy (NIRS).

Conditions

Parkinson's Disease

Keywords

Parkinson's disease; Auditory Cueing

Outcome Measures

Primary Outcomes (4)

• Finger Tapping

  Record pre-test and post-test change.

  Baseline,45-60 minutes.

• Motor evoked potential

  Use single-pulse TMS to assess Motor evoked potential change.

  Baseline,45-60 minute

• Intracortical inhibition & Intracortical facilitation

  Use paired-pulse TMS to record pre-test and post-test change.

  Baseline,45-60 minutes

• Blood oxygen dependent level

  Use Near-infrared spectroscopy to record pre-test, in experiment, and post-test change.

  Baseline, in experiment,45-60 minutes

Study Arms (2)

intervention group

EXPERIMENTAL

intervention group which receive auditory cueing while performing movement

Procedure: rhythmic auditory stimulation

Control group

NO INTERVENTION

control group which performing movement after listen to required movement rhythm.

Interventions

rhythmic auditory stimulation PROCEDURE

Participants perform the finger tapping at the same time give rhythmic auditory stimulation ,and need to execute tapping with auditory stimulation.

intervention group

Eligibility Criteria

• Age: 20 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Clinical diagnosis of Parkinson disease

You may not qualify if:

• Clinical diagnosis of other neurological diseases
• Dementia
• Been diagnosed with any mental illness
• History of seizures
• Brain trauma
• Body with a pacemaker or other electrical stimulator
• Pregnancy

Sponsors & Collaborators

• Chang Gung University: lead

Study Sites (1)

Chang Gung University

Taoyuan District, 333, Taiwan

RECRUITING

MeSH Terms

Conditions

Parkinson Disease

Condition Hierarchy (Ancestors)

Parkinsonian Disorders; Basal Ganglia Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Movement Disorders; Synucleinopathies; Neurodegenerative Diseases

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Profesor

Study Record Dates

• First Submitted: January 14, 2014
• First Posted: January 16, 2014
• Study Start: August 1, 2013
• Primary Completion: August 1, 2014
• Study Completion: August 1, 2014
• Last Updated: January 16, 2014

Record last verified: 2014-01

Locations

TW (1)