Adductor Canal Versus Femoral Nerve Block for Analgesia Post Total Knee Arthroscopy

NCT02033603 | Unknown

• 1 other identifier: 2013/ 921/ D
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

Total knee arthroplasty or replacement (TKA) is a surgery performed for osteoarthritis of the knee which is increasingly performed as the population ages. It is a painful surgery and one of the methods to reduce post-operative pain is performing a regional anaesthesia technique. The current practice is to perform a femoral nerve block (FNB) which blocks the nerves supplying the knee joint and the thigh muscles (quadriceps). This provides effective analgesia. However, it also results in weakness of the quadriceps and may result in falls post-operatively. Adductor canal block (ACB) is a new, alternative regional anaesthesia technique which is hypothesised to provide as effective analgesia, with less quadriceps weakness compared to FNB, hence potentially reducing the risk of falls post-operatively. Investigators aim to study if the analgesia provided by ACB is as good as FNB while preserving quadriceps strength.

Conditions

Knee Osteoarthritis

Keywords

Total knee arthroplasty; Total knee replacement; Femoral Nerve Block; Adductor Canal Block

Outcome Measures

Primary Outcomes (1)

• Morphine consumption

  first 24 hours

Secondary Outcomes (4)

• Pain scores

  1, 6, 12, 24, 48

• Morphine consumption

  48 hours

• Side effects of opioids- sedation, nausea and vomiting

  48 hours

• Quadriceps strength, ability to mobilise

  24, 48 hours

Study Arms (2)

Femoral Nerve Block

ACTIVE COMPARATOR

Femoral Nerve block performed with 0.5% Ropivacaine 30mls (150mg)

Drug: Ropivacaine

Adductor Canal block

ACTIVE COMPARATOR

Adductor Canal block performed with 0.5% Ropivacaine 30mls (150mg)

Drug: Ropivacaine

Interventions

Ropivacaine DRUG

30mls of 0.5% ropivacaine

Also known as: naropin

Adductor Canal block; Femoral Nerve Block

Eligibility Criteria

• Age: 45 Years - 85 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• ages 45-85
• American Society of Anaesthesiologists physical status 1-3
• BMI 18-35 kg/m2

You may not qualify if:

• inability to give consent, communicate, cooperate
• Patients with regular consumption of strong opioids (morphine, oxycodone) or steroids
• Patients with allergy to local anaesthetics or any drugs included in the study
• Patients with lower limb surgery in the preceding year
• Patients with pre-existing neurological deficits
• Patients who are unsuitable for general anaesthetics (eg difficult airway)

Sponsors & Collaborators

• Changi General Hospital: lead

Study Sites (1)

Changi General Hospital

Singapore, 529889, Singapore

RECRUITING

MeSH Terms

Conditions

Osteoarthritis, Knee

Interventions

Ropivacaine

Condition Hierarchy (Ancestors)

Osteoarthritis; Arthritis; Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases

Intervention Hierarchy (Ancestors)

Anilides; Amides; Organic Chemicals; Aniline Compounds; Amines

Study Officials

• Yean Chin Lim, MBBS, MMed

  Changi General Hospital

  PRINCIPAL INVESTIGATOR

Central Study Contacts

CTRU CGH

CONTACT

67888833

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 9, 2014
• First Posted: January 13, 2014
• Study Start: January 1, 2014
• Primary Completion: September 1, 2014
• Study Completion: December 1, 2014
• Last Updated: January 1, 2015

Record last verified: 2014-01

Locations

SG (1)