The Feasibility of PetCO2 Prediction Hypotension Under Spinal Anesthesia for Cesarean Section

NCT02032355 | Unknown

• 1 other identifier: 61538
• Study Type: observational
• Target: 6
• Locations: 1 country
• Sites: 1

Brief Summary

Maternal hypotension is a common side effect after spinal anesthesia for cesarean delivery.Decreased vascular resistance and cardiac output, due to sympathetic blockade1and blood pooling in blocked areas of the body respectively, are main causes of spinal anaesthesia-induced hypotension during Caesarean delivery. Cardiac output, which has shown to be a better predictor of organ and placental perfusion than arterial blood pressure.Few studies have measured CO after spinal anesthesia in the maternal population.This is largely because of the lack of availability of accurate and reproducible noninvasive measurement techniques. Up to now, preventing hypotension has continued to focus on arterial blood pressure variables, fluid, and ephedrine requirements as markers of cardiovascular status, because these are more easily measured. Investgators hypothesized that CO and PetCO2, in parturients with the degree of hypotension during spinal anaesthesia, would also have a positive and significant association.

Conditions

Hypotension; Carbon Dioxide

Outcome Measures

Primary Outcomes (1)

• value of PetCO2 and changes in artery pressure

  up to 4 weeks

Study Arms (1)

hypotension

Procedure: spinal anesthesia

Interventions

spinal anesthesia PROCEDURE

hypotension

Eligibility Criteria

• Age: 20 Years - 40 Years
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64)
• Sampling Method: Probability Sample

Study Population

American Society of Anesthesiologists physical status I and II patients undergoing elective cesarean delivery under combined spinal-epidural (CSE) anesthesia

You may qualify if:

• full-term gestation (\>36 and \<41 weeks of gestation) with a singleton pregnancy

You may not qualify if:

• emergency cases
• placenta praevia
• preeclampsia
• cardiovascular or cerebrovascular disease
• morbid obesity with a BMI≥40
• contraindications to spinal anaesthesia

Sponsors & Collaborators

• Geng guiqi: lead

Study Sites (1)

Obstetrics & Gynecology Hospital, Fudan University

Shanghai, Shanghai Municipality, 200090, China

RECRUITING

MeSH Terms

Conditions

Hypotension

Interventions

Anesthesia, Spinal

Condition Hierarchy (Ancestors)

Vascular Diseases; Cardiovascular Diseases

Intervention Hierarchy (Ancestors)

Anesthesia, Conduction; Anesthesia; Anesthesia and Analgesia

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: professor

Study Record Dates

• First Submitted: January 7, 2014
• First Posted: January 10, 2014
• Study Start: January 1, 2014
• Primary Completion: February 1, 2014
• Study Completion: February 1, 2014
• Last Updated: January 10, 2014

Record last verified: 2014-01

Locations

CN (1)