Can Oxytocin Level Predict Postpartum Depression?
Can Prenatal Plasma Oxytocin Concentration Predict Likelihood of Postpartum Depression? An Opportunity for Early Intervention and Prevention in a Vulnerable Population
1 other identifier
observational
68
1 country
1
Brief Summary
The goal of this research study is to understand the relationship between the hormone oxytocin and postpartum mood.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for all trials
Started Dec 2013
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
December 1, 2013
CompletedFirst Submitted
Initial submission to the registry
December 12, 2013
CompletedFirst Posted
Study publicly available on registry
December 24, 2013
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 1, 2015
CompletedStudy Completion
Last participant's last visit for all outcomes
August 1, 2015
CompletedOctober 26, 2023
October 1, 2023
1.5 years
December 12, 2013
October 24, 2023
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Inventory of Depressive Symptomatology, Self-Report (IDS-SR-30)
The IDS-SR-30 is a validated, widely used tool to evaluate depressive symptoms and clinical depression. Participants will complete this questionnaire in person or through telephone interview.
4-6 weeks post delivery
Eligibility Criteria
Healthy Pregnant Women
You may qualify if:
- At least 18 years of age
- English-speaking
- Pregnant (third trimester at time of visit)
You may not qualify if:
- Current active depression or other mental illness at time of study entry in the third trimester (past depression or anxiety is acceptable)
- Current antidepressant treatment
- Severe medical complications in current pregnancy (gestational diabetes, hypertension, thyroid disease)
- Signs of multiple gestation or of fetal malformation in current pregnancy
- Cigarette smoking beyond 10th week of gestation of current pregnancy
- Pre-pregnancy BMI \> 32
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Northwestern Universitylead
- Northwestern Memorial Hospitalcollaborator
Study Sites (1)
Northwestern Memorial Hospital
Chicago, Illinois, 60611, United States
Related Publications (1)
Bell AF, Carter CS, Steer CD, Golding J, Davis JM, Steffen AD, Rubin LH, Lillard TS, Gregory SP, Harris JC, Connelly JJ. Interaction between oxytocin receptor DNA methylation and genotype is associated with risk of postpartum depression in women without depression in pregnancy. Front Genet. 2015 Jul 21;6:243. doi: 10.3389/fgene.2015.00243. eCollection 2015.
PMID: 26257770RESULT
Related Links
Biospecimen
A 3 milliliter (about half a teaspoon) blood sample will be obtained to measure oxytocin level.
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Suena H Massey, MD
Northwestern University
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
December 12, 2013
First Posted
December 24, 2013
Study Start
December 1, 2013
Primary Completion
June 1, 2015
Study Completion
August 1, 2015
Last Updated
October 26, 2023
Record last verified: 2023-10