NCT02018211

Brief Summary

Numerous techniques are reported to enhance recovery following intense exercise, however there is equivocal support for such claims. A novel technique of neuromuscular electrical stimulation (NMES) via the peroneal nerve has been shown to augment limb blood flow which could enhance recovery following exercise. The present study examined the effects of NMES, compared to graduated compression socks on muscle soreness, strength, and markers of muscle damage and inflammation following intense intermittent exercise.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
21

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Dec 2012

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

December 1, 2012

Completed
3 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

March 1, 2013

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

March 1, 2013

Completed
10 months until next milestone

First Submitted

Initial submission to the registry

December 17, 2013

Completed
6 days until next milestone

First Posted

Study publicly available on registry

December 23, 2013

Completed
Last Updated

June 26, 2015

Status Verified

June 1, 2015

Enrollment Period

3 months

First QC Date

December 17, 2013

Last Update Submit

June 25, 2015

Conditions

Delayed Onset Muscle Soreness

Keywords

delayed onset muscle sorenessmuscle damagemuscle functioninflammation

Outcome Measures

Primary Outcomes (1)

  • Perceived muscle soreness (PMS)

    perceived muscle soreness (PMS), often referred to as delayed onset muscle soreness (DOMS)

    72hrs

Secondary Outcomes (1)

  • muscle strength

    72hrs

Other Outcomes (1)

  • measurement of CK and LDH activity and IL-6, CRP and TBAR concentrations

    72 hrs

Study Arms (1)

experimental group

EXPERIMENTAL

All participants performed a modified version of the Loughborough Intermittent Shuttle Test (LIST; Nicholas et al, 2000), an exercise protocol designed to simulate the activity pattern characteristics of intermittent sports such as soccer. The LIST was performed on three occasions, at the same time of day, each separated by approximately four weeks. Following each exercise trial, one of three recovery interventions were applied, the order of which were randomly allocated.

Other: controlDevice: graduated compression socksDevice: neuromuscular electrical stimulation device

Interventions

controlOTHER

passive recovery following exercise test

experimental group
graduated compression socksDEVICE

graduated compression socks worn after test exercise

experimental group
neuromuscular electrical stimulation deviceDEVICE

neuromuscular electrical stimulation device worn after test exercise

Also known as: firefly device
experimental group

Eligibility Criteria

Age20 Years - 22 Years
Sexmale
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • healthy males
  • currently playing intermittent sports (such as soccer, field hockey, rugby)
  • currently representing their respective sports at either university, county, national or international levels

You may not qualify if:

  • unhealthy males
  • not currently playing intermittent sports (such as soccer, field hockey, rugby)
  • not currently representing their respective sports at either university, county, national or international levels
  • individuals indicating a history of cardiovascular, metabolic or haematological disorders
  • participants reporting a sedentary lifestyle of less than three 30-min physical activity sessions per week

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

School of Sport, Exercise and Health Sciences

Loughborough, Leicestershire, LE11 3TU, United Kingdom

Location

Related Publications (1)

  • Ferguson RA, Dodd MJ, Paley VR. Neuromuscular electrical stimulation via the peroneal nerve is superior to graduated compression socks in reducing perceived muscle soreness following intense intermittent endurance exercise. Eur J Appl Physiol. 2014 Oct;114(10):2223-32. doi: 10.1007/s00421-014-2943-5. Epub 2014 Jul 11.

    PMID: 25011496RESULT

MeSH Terms

Conditions

Inflammation

Condition Hierarchy (Ancestors)

Pathologic ProcessesPathological Conditions, Signs and Symptoms

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NA
Masking
NONE
Purpose
BASIC SCIENCE
Intervention Model
SINGLE GROUP
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

December 17, 2013

First Posted

December 23, 2013

Study Start

December 1, 2012

Primary Completion

March 1, 2013

Study Completion

March 1, 2013

Last Updated

June 26, 2015

Record last verified: 2015-06

Locations

GB(1)