Moxifloxacin in Situ Gel to Treat Periodontal Pocket.
Moxifloxacin In Situ Gel as an Adjunct in the Treatment of Periodontal Pocket: A Randomized Clinical Trial.
1 other identifier
interventional
5
1 country
1
Brief Summary
In this Randomized clinical trial locally delivered moxifloxacin in situ gel was evaluated as an adjunct to scaling and root planing for efficacy in the treatment of chronic periodontitis and for short-term effects on the periodontal microflora.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for phase_4
Started Sep 2011
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
September 1, 2011
CompletedPrimary Completion
Last participant's last visit for primary outcome
November 1, 2012
CompletedStudy Completion
Last participant's last visit for all outcomes
November 1, 2012
CompletedFirst Submitted
Initial submission to the registry
November 6, 2013
CompletedFirst Posted
Study publicly available on registry
December 19, 2013
CompletedAugust 13, 2020
August 1, 2020
1.2 years
November 6, 2013
August 10, 2020
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Change from baseline in Clinical attachment level at 3 months in chronic periodontitis patients
The present randomized clinical trial assessed the effects of moxifloxacin, compared with chlorhexidine, locally administered via in situ gel formulation, on various clinical parameters describing periodontitis.
3 months
Study Arms (1)
Moxifloxacin, Chronic periodontitis
EXPERIMENTAL50 micrograms Moxifloxacin
Interventions
TO ASSESS THE EFFICACY OF MOXIFLOXACIN IN SITU GEL IN THE TREATMENT OF PERIODONTAL POCKET.
Eligibility Criteria
You may qualify if:
- patients with good systemic health
- Patients with Chronic periodontitis with sites with probing pocket depth (PPD) of ≥ 5 mm
- a minimum of 12 natural teeth with radiographic evidence of bone loss
- willingness to comply with the study protocol.
You may not qualify if:
- Patients with a history of drug allergy to quinolones or those who were taking medication that might interact with moxifloxacin
- Patients with history of antibiotic coverage in the 6 months preceding the study
- Pregnant or lactating patients.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Sri Hasanamba Dental College & Hospital
Hassan, Karnataka, 573201, India
Related Publications (1)
Guentsch A, Jentsch H, Pfister W, Hoffmann T, Eick S. Moxifloxacin as an adjunctive antibiotic in the treatment of severe chronic periodontitis. J Periodontol. 2008 Oct;79(10):1894-903. doi: 10.1902/jop.2008.070493.
PMID: 18834244BACKGROUND
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Shaurya Manjunath, MDS
Rajiv Gandhi University of Health Sceinces, Bangalore,Karnataka, India
Study Design
- Study Type
- interventional
- Phase
- phase 4
- Allocation
- NA
- Masking
- NONE
- Purpose
- TREATMENT
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Shaurya Manjunath, Post graduate Student, Department of Periodontology
Study Record Dates
First Submitted
November 6, 2013
First Posted
December 19, 2013
Study Start
September 1, 2011
Primary Completion
November 1, 2012
Study Completion
November 1, 2012
Last Updated
August 13, 2020
Record last verified: 2020-08