Polymorphonuclear Cells' Sensitivity to Aggregatibacter Actinomycetemcomitans Bacteria in Patients With Aggressive Periodontitis
1 other identifier
interventional
75
1 country
1
Brief Summary
aggressive periodontitis is an inflammatory disease which damage the teeth supporting structures mostly in young patients. and has genetic basis. a specific bacteria: Aggregatibacter actinomycetemcomitans (Aa) is associated with this disease, and found to damage leukocytes by using a specific leukotoxin. in the research the investigators are aiming to find molecular and immunological basis to aggressive periodontitis.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for not_applicable
Started Jan 2014
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
December 9, 2013
CompletedFirst Posted
Study publicly available on registry
December 12, 2013
CompletedStudy Start
First participant enrolled
January 1, 2014
CompletedPrimary Completion
Last participant's last visit for primary outcome
January 1, 2015
CompletedStudy Completion
Last participant's last visit for all outcomes
October 1, 2015
CompletedDecember 16, 2013
December 1, 2013
1 year
December 9, 2013
December 13, 2013
Conditions
Outcome Measures
Primary Outcomes (1)
flow cytometry
the investigators use flow cytometry technique in order to determine the influence of gingival bacteria on the leukocytes, after culturing the two together.
12 hours after blood extraction
Secondary Outcomes (1)
microscopy observation
12 hours after blood extraction
Study Arms (3)
aggressive periodontitis
EXPERIMENTAL25 patients with aggressive periodontitis blood extraction
chronic periodontitis
EXPERIMENTAL25 patients with chronic periodontitis blood extraction
healthy
EXPERIMENTAL25 healthy periodontal patients blood extraction
Interventions
6 ml blood extraction from each patients in all 3 arms of the study
Eligibility Criteria
You may qualify if:
- patients in periodontal department
- healthy
- diagnosed with chronic/aggressive periodontal disease
- interested in participating the research
You may not qualify if:
- diagnosed with diabetes, heart disease, immunosuppression, thrombocytopenia, clotting enzyme deficiency.
- using alcohol, or drugs
- pregnancy
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Polak Davidlead
Study Sites (1)
Hadassah Medical Organization, Jerusalem, Israel
Jerusalem, Israel
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
David Polak, DMD, PhD
Haddasah Medical Center
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NON RANDOMIZED
- Masking
- NONE
- Purpose
- BASIC SCIENCE
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR INVESTIGATOR
- PI Title
- senior dentist, periodontology department
Study Record Dates
First Submitted
December 9, 2013
First Posted
December 12, 2013
Study Start
January 1, 2014
Primary Completion
January 1, 2015
Study Completion
October 1, 2015
Last Updated
December 16, 2013
Record last verified: 2013-12