Multimodality Prediction of Success of Atrial Fibrillation Rhythm Control Strategy

NCT02009683 | Unknown DMC

• 1 other identifier: METC 13-2-033.3
• Study Type: observational
• Target: 220
• Locations: 1 country
• Sites: 1

Brief Summary

In this study the investigators aim to build a model to predict the maintenance of sinus rhythm (SR) after successful direct current cardioversion (DCC) incorporating standard predictors such as echocardiographic parameters, clinical parameter and 12-lead ECG parameters and new parameters, including 17-lead ECG, Oesophageal-ECG and single nucleotide polymorphisms (SNPs). Using this novel integrated prediction model will help in the identification of patients who will maintain SR after cardioversion. Another innovative aspect of our study is the use of daily rhythm monitoring using a versatile device (MyDiagnostick®). The clinical impact this study will have is that it helps the cardiologist to make a patient tailored strategy in the treatment of AF as advocated by the guidelines and to prevent exposing patients not likely to maintain SR to the potentially harmful side-effect of a rhythm-control strategy. Primary objectives To show that a model incorporating the novel predictors 17-lead ECG, Oesophageal-ECG and SNPs is superior to existing models in predicting maintenance of sinus rhythm after successful DCC in patients with persistent AF. Secondary objectives To assess the predictive value of new predictors (the Oesophageal-ECG, 17-lead ECG and SNPs) for maintenance of SR after successful DCC separately. To assess the predictive value of new predictors (the Oesophageal-ECG, 17-lead ECG and SNPs) for time to recurrence of AF. To assess the predictive value of predictors with respect to complete failure of cardioversion. To assess the predictive value of predictors with respect to cardiovascular morbidity. Hypothesis The investigators hypothesise that a model incorporating the novel predictors the 17-leads ECG, Oesophageal-ECG and SNPs performs significantly better than existing models using only clinical, echocardiographic and ECG parameters on a standard 12-lead ECG in predicting maintenance of SR after successful DCC. In addition the investigators hypothesise that Oesophageal-ECG is the best single predictor for maintenance of SR after successful DCC.

Conditions

Atrial Fibrillation

Outcome Measures

Primary Outcomes (1)

• Maintenance of sinus rhythm after successful direct current cardioversion

  6 months

Secondary Outcomes (3)

• Failure of direct current cardioversion

  1 day

• Cardiovascular mortality

  6 months

• Hospitalisation for cardiovascular events

  6 months

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients with persistent atrial fibrillation scheduled for direct current cardioversion.

You may qualify if:

• Haemodynamic stable patients with persistent AF scheduled for DCC.
• Written informed consent.
• Patients \> 18 years old.

You may not qualify if:

• Atrial flutter at time of DCC.
• Patients with known oesophageal disease.
• Patients with previous operations on throat or oesophagus.
• Postoperative atrial fibrillation.
• Patients with previous ablation for AF.
• Patients on anti-arrhythmic drugs (AAD).
• Patients with pacemakers unable to detect AF and with a regular paced rhythm during AF.
• Planned ablation for AF.
• Myocardial infarction within the last 4 weeks.

Sponsors & Collaborators

• Maastricht University Medical Center: lead

Study Sites (1)

Maastricht University Medical Centre

Maastricht, Netherlands

RECRUITING

Biospecimen

Retention: SAMPLES WITH DNA

Blood biomarkers and SNPs

MeSH Terms

Conditions

Atrial Fibrillation

Condition Hierarchy (Ancestors)

Arrhythmias, Cardiac; Heart Diseases; Cardiovascular Diseases; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• H Crijns, MD, PhD

  Maastricht University Medical Centre

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Theo Lankveld, MD

CONTACT

+31433871611; theo.lankveld@mumc.nl

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 9, 2013
• First Posted: December 12, 2013
• Study Start: May 1, 2014
• Primary Completion: September 1, 2018
• Study Completion: September 1, 2018
• Last Updated: April 26, 2018

Record last verified: 2018-04

Locations

NL (1)