Effect of Desflurane on Cardiac Function During Cardiac Surgery: Tissue Doppler Imaging of Mitral Valve Annular Velocity

NCT02003885 | Unknown DMC

• 1 other identifier: KUH1160063
• Study Type: interventional
• Target: 14
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to determine desflurane's dose-dependent effect on left ventricular (LV) function in cardiac surgery. The change of tissue Doppler imaging (TDI) of lateral mitral valve annular velocity at three different desflurane concentrations would be analyzed by using intraoperative transesophageal echocardiography (TEE) in cardiac surgery patients

Conditions

Valvular Heart Disease

Keywords

Desflurane, mitral annular velocity, tissue Doppler imaging

Outcome Measures

Primary Outcomes (1)

• Peak systolic mitral annular velocity (S')

  Peak systolic mitral annular velocity (S') using tissue Doppler imaging By using pulsed Doppler with the sample volume positioned at the lateral mitral valve (MV)ring in the midesophageal 4-chamber view, S' would be determined just after the 10 min-exposure to each concentration of desflurane, 0.5 MAC, 1.0 MAC and 1.5 MAC (T1, T2 and T3, respectively)

  after 10 min exposure to desflurane 0.5, 1.0 and 1.5 MAC

Secondary Outcomes (1)

• diastolic mital annular veocities (E' and A'), ejection fraction (EF), Bispectral index

  after 10 min exposure to desflurane 0.5, 1.0 and1.5 MAC

Study Arms (1)

Desflurane increment

EXPERIMENTAL

increment of desflurane 0.5-1.5 MAC in remifentanil anesthesia for cardiac surgery

Drug: increment of desflurane

Interventions

increment of desflurane DRUG

After achieving stable hemodynamics and BIS 40-60 with desflurnae 0.5 MAC and remifentanil 0.7-1.0 mcg/kg/min (T1), data including S', E', A', EF, E, A and BIS are determined. After 10 min exposure to the increased desflurane dosage 1.0 MAC (T2), data are determiend. After 10 min exposure to the increased desflurane dosage 1.5 MAC (T3), data are determined. Reduction of BP is managed by the increment of phenylephrine infusion

Also known as: Desflurane inhalation 0.5 MAC, 1.0 MAC and 1.5 MAC

Desflurane increment

Eligibility Criteria

• Age: 20 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients undergoing cardiac surgery

You may not qualify if:

• Low ejection fraction \<50% in preoperative transthoracic echocardiography
• Atrial fibrillation
• Pacemaker
• Pericardial and infiltrative myocardial disease
• Mitral annular calcification, surgical rings, prosthetic mitral valves
• Lateral left ventricular regional wall motion abnormality
• Esophageal spasm, stricture, laceration, perforation, and diverticulum
• Diaphragmatic hernia
• History of extensive radiation to mediastinum
• Upper gastrointestinal bleeding

Sponsors & Collaborators

• Konkuk University Medical Center: lead

Study Sites (1)

Konkuk University Medical Center

Seoul, Seoul, 143729, South Korea

RECRUITING

MeSH Terms

Conditions

Heart Valve Diseases

Condition Hierarchy (Ancestors)

Heart Diseases; Cardiovascular Diseases

Study Officials

• Tae-Yop Kim, MD, PhD

  Konkuk University Medical Center

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Tae-Yop Kim, MD, PhD

CONTACT

82-10-8811-6942

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: DIAGNOSTIC
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor of Anesthesiology

Study Record Dates

• First Submitted: August 28, 2013
• First Posted: December 6, 2013
• Study Start: January 1, 2014
• Primary Completion: August 1, 2015
• Study Completion: September 1, 2015
• Last Updated: March 6, 2015

Record last verified: 2015-03

Locations

KR (1)