Comparison of Both Metabolic and Functional Effects Induced by Two Neuromuscular Electrical Stimulation Protocols: A Comprehensive Approach Using Magnetic Resonance Imaging and Spectroscopy

NCT02001675 | Unknown

• 2 other identifiers: 2012-A01265-382012-32
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

Neuromuscular electrical stimulation (NMES) has emerged as a suitable tool for restoring, maintaining and/or enhancing muscular performance. From a practical point of view, NMES can elicit contractions either by direct activation of motor axons (i.e. peripheral mechanism) or by the recruitment of motoneurons in the spinal cord through the depolarization of sensory axons (central mechanism). It is noteworthy that NMES parameters widely affect the balance between transmission along these two pathways. Conventional NMES is usually delivered using short pulse duration (0.05-0.4 ms), low stimulation frequency (15-40 Hz) and high stimulus intensities so that the large antidromic volley in motor axons ensures that the evoked contraction will be driven largely by the direct depolarization of motor axons beneath the stimulation site with no or little involvement of central nervous system. On the contrary, when NMES is delivered using wide pulse widths (1 ms) and high frequency (up to 100 Hz) (WP-HF NMES), a portion of the evoked contraction arises from a central mechanism and the corresponding force (recently referred to as "extra force") is significantly (three times) larger than the conventional NMES-induced force. This extra force is supposed to represent the central contribution from the recruitment of spinal motoneurons by the evoked afferent volley given that no additional force was observed during a complete anesthetic block of the nerve proximal to the stimulation site. Despite the obvious differences in terms of activation of the neuromuscular system between conventional and WP-HF NMES, the functional, metabolic and cortical responses associated to both protocols remain to be determined

Conditions

Healthy

Keywords

Neuromuscular electrical stimulation (NMES)

Outcome Measures

Primary Outcomes (1)

• RMI

  Assessment of muscle function or brain

  36 months

Study Arms (1)

Volunteer healthy

EXPERIMENTAL

Device: magnetic resonance imaging (MRI); Device: 31-phosphorous magnetic resonance spectroscopy (MRS-P31)

Interventions

magnetic resonance imaging (MRI) DEVICE

Volunteer healthy

31-phosphorous magnetic resonance spectroscopy (MRS-P31) DEVICE

Volunteer healthy

Eligibility Criteria

• Age: 18 Years - 45 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• age included between 18 and 45 years
• The volunteers will have to benefit from a social security cover.
• The selected subjects will have to be unhurt of any general disease, psychiatric disorders and any infectious, inflammatory, tumoral, vascular, degenerative or traumatic pathology.
• They will have to follow no chronic treatment and will have to be unhurt of any history of alcoholism or drug addiction.

You may not qualify if:

• Usual contraindications for an examination MRI.
• So, will not be included, the subjects:
• suffering from claustrophobia,
• having stimulating one cardiac, carriers of a system Holter,
• carriers of hook(staple) (clip) surgical metallic,
• Carriers of a prosthesis or a metallic implant (or quite different metallic foreign bodies),
• carriers of a prosthesis dental (device),
• carriers of a hearing aid,
• carriers of an insulin pump,
• having been hurt by pieces of shrapnel or lead,
• Having followed a treatment(processing) with anti-inflammatory drugs during the last 3 months, having followed a treatment(processing) with amino acids during 3

Sponsors & Collaborators

• Assistance Publique Hopitaux De Marseille: lead

Study Sites (1)

Assistance Publique Hopitaux de Marseille

Marseille, 13354, France

Location

MeSH Terms

Interventions

Magnetic Resonance Imaging

Intervention Hierarchy (Ancestors)

Tomography; Diagnostic Imaging; Diagnostic Techniques and Procedures; Diagnosis

Study Officials

• michele DAMON

  Assistance Publique Hopitaux De Marseille

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: DIAGNOSTIC
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 21, 2012
• First Posted: December 5, 2013
• Study Start: December 1, 2012
• Primary Completion: December 1, 2015
• Study Completion: June 1, 2016
• Last Updated: December 5, 2013

Record last verified: 2013-11

Locations

FR (1)