NCT02001649

Brief Summary

Suicidal behaviors is known to aggregate in families. The purpose of this study is to evaluate association between common polymorphisms in genes important for neurobiological pathways linked to suicidal behaviors and suicide attempt among adolescents patient.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
250

participants targeted

Target at P75+ for not_applicable

Timeline
Completed

Started Dec 2013

Typical duration for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

November 14, 2013

Completed
17 days until next milestone

Study Start

First participant enrolled

December 1, 2013

Completed
4 days until next milestone

First Posted

Study publicly available on registry

December 5, 2013

Completed
2.6 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

July 1, 2016

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

July 1, 2016

Completed
Last Updated

April 16, 2026

Status Verified

April 1, 2026

Enrollment Period

2.6 years

First QC Date

November 14, 2013

Last Update Submit

April 13, 2026

Conditions

Attempt Suicide

Keywords

suicideadolescentgeneticSNP

Outcome Measures

Primary Outcomes (1)

  • Odds ratio (OR) and 95% confidence interval (CI) will be estimated using a logistic regression model to assessing the contribution of each polymorphism as a risk factor in predicting suicidal behavior

    Measure is a composite outcome measure consisting of multiple measures Post hoc Bonferroni correction will be employed to correct for multiple testing. Chi- square test will performed to analyze genetic associations

    Between day 1 and day 5 during hospitalization

Study Arms (2)

Inpatient group SNP Genotyping

OTHER

Patients will be recruited from pediatric departments in which 13 -17 y old adolescents are hospitalized for a suicide attempt. Data will be collected through self-administered questionnaires and face to face interview. DNA will be extracted from saliva sample. Individuals will be genotyped at a total of 96 SNPs

Genetic: SNP Genotyping

Control group SNP Genotyping

OTHER

Control subjects are young adults without suicide attempt and without mental disorders

Genetic: SNP genotyping

Interventions

SNP genotypingGENETIC

Individuals were genotyped at a total 96 SNP from 15 candidate gene

Inpatient group SNP Genotyping

Eligibility Criteria

Age13 Years - 17 Years
Sexall
Healthy VolunteersYes
Age GroupsChild (0-17)

You may qualify if:

  • Case :
  • Age at admission between 13 and 17 years old
  • Hospitalized for attempted suicide
  • Absence of prominent mental retardation or organic brain damage
  • Fluent in French
  • Able to comprehend the study procedures and to undergo entry assessments safely
  • Provided written informed consent for study participation, and additional consent from the patient's parents or guardians
  • Northern and Western European ancestry (HapMap-CEU)
  • Medical insurance coverage
  • Control :
  • Healthy adult volunteers
  • No present or past psychiatric illness
  • No personal history of suicidal behavior and without a family history of suicide
  • Provided written informed consent for study participation
  • Northern or Western European ancestry (HapMap-CEU)
  • +1 more criteria

You may not qualify if:

  • Case:
  • Inability to get an informed and valid consent
  • Home address outside the selected hospitals' geographic areas
  • Intellectual disability or organic brain damage
  • Origine ethnique non CEU
  • Absence of medical insurance coverage
  • Pregnant or lactating women
  • Without Northern or Western European ancestry (HapMap-CEU)
  • Control :
  • Inability to get an informed and valid consent
  • Intellectual disability or organic brain damage
  • History of suicidal behavior
  • Psychiatric disorder, past or present
  • Family history of suicide
  • Borderline personality disorder
  • +3 more criteria

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Chu Rouen

Rouen, Haute Normandie, 76000, France

Location

Related Publications (1)

  • Mirkovic B, Cohen D, Laurent C, Lasfar M, Marguet C, Gerardin P. A case-control association study of 12 candidate genes and attempted suicide in French adolescents. Int J Adolesc Med Health. 2017 Sep 13;32(1):/j/ijamh.2020.32.issue-1/ijamh-2017-0089/ijamh-2017-0089.xml. doi: 10.1515/ijamh-2017-0089.

    PMID: 28902619RESULT

MeSH Terms

Conditions

Suicide, AttemptedSuicide

Condition Hierarchy (Ancestors)

Self-Injurious BehaviorBehavioral SymptomsBehavior

Study Officials

  • BOJAN MIRKOVIC, MD

    CHU Rouen, Fédération de pédopsychiatrie du Pr Gérardin

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NON RANDOMIZED
Masking
NONE
Purpose
SCREENING
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

November 14, 2013

First Posted

December 5, 2013

Study Start

December 1, 2013

Primary Completion

July 1, 2016

Study Completion

July 1, 2016

Last Updated

April 16, 2026

Record last verified: 2026-04

Locations

FR(1)