Remifentanil and Nitroprusside for Controlled Hypotension

NCT02001298 | Completed

• 1 other identifier: HJKim3
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is the comparison of the cardiovascular effects of remifentanil and nitroprusside for controlled hypotension

Conditions

Hypotension, Controlled

Keywords

remifentanil; nitroprusside; hypotension

Outcome Measures

Primary Outcomes (1)

• Cardiac index

  Cardiac index was continuously measured during controlled hypotension using noninvasive cardiac output monitor. The average of cardiac index during controlled hypotension was compared with baseline value.

  Cardiac index was continuously measured during controlled hypotension, an average of 90 min

Secondary Outcomes (1)

• Total peripheral resistance index

  Total peripheral resistance index was continuously measured during controlled hypotension, an average of 90 min

Other Outcomes (1)

• Stroke volume index

  Stroke volume index was continuously measured during controlled hypotension, an average of 90 min

Study Arms (2)

nitroprusside

EXPERIMENTAL

After induction of anesthesia, controlled hypotension was induced with continuous infusion of nitroprusside. Cardiac index, stroke volume index, and total peripheral resistance index were continuously measured using noninvasive cardiac output monitor (Cheetah NICOM, Cheetah Medical Inc, UK).

Drug: nitroprusside

remifentanil

EXPERIMENTAL

After induction of anesthesia, controlled hypotension was induced with continuous infusion of remifentanil. Cardiac index, stroke volume index, and total peripheral resistance index were continuously measured using noninvasive cardiac output monitor (Cheetah NICOM, Cheetah Medical Inc, UK).

Drug: remifentanil

Interventions

remifentanil DRUG

remifentanil

nitroprusside DRUG

nitroprusside

Eligibility Criteria

• Age: 20 Years - 60 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Patients who underwent endoscopic sinus surgery

You may not qualify if:

• patient who took any drug to influence this study
• patient with cardiovascular disease, renal disease or liver disease

Sponsors & Collaborators

• Jeju National University School of Medicine: lead

Study Sites (1)

Jeju National University Hospital

Jeju City, Jeju Special Self-Governing Province, 690-767, South Korea

Location

MeSH Terms

Conditions

Hypotension

Interventions

Remifentanil; Nitroprusside

Condition Hierarchy (Ancestors)

Vascular Diseases; Cardiovascular Diseases

Intervention Hierarchy (Ancestors)

Propionates; Acids, Acyclic; Carboxylic Acids; Organic Chemicals; Piperidines; Heterocyclic Compounds, 1-Ring; Heterocyclic Compounds; Ferricyanides; Cyanides; Anions; Ions; Electrolytes; Inorganic Chemicals; Ferric Compounds; Iron Compounds; Hydrogen Cyanide; Nitrogen Compounds

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant professor

Study Record Dates

• First Submitted: November 24, 2013
• First Posted: December 4, 2013
• Study Start: June 1, 2012
• Primary Completion: July 1, 2013
• Last Updated: December 4, 2013

Record last verified: 2013-11

Locations

KR (1)