Requirement of Propofol for Induction of Unconsciousness in Patients With Parkinson's Disease
1 other identifier
observational
62
1 country
1
Brief Summary
Parkinson's disease (PD) is the second most prevalent neurodegenerative disease. The investigators clinical experience showed a trend of delayed emergence among patients undergoing deep brain stimulator (DBS) implantation and pulse generator placement under general anesthesia. Abnormal pharmacodynamics might be present among these patients, which had never been investigated.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for all trials
Started Jan 2012
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
January 1, 2012
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 1, 2013
CompletedStudy Completion
Last participant's last visit for all outcomes
June 1, 2013
CompletedFirst Submitted
Initial submission to the registry
November 19, 2013
CompletedFirst Posted
Study publicly available on registry
November 28, 2013
CompletedNovember 28, 2013
November 1, 2013
1.4 years
November 19, 2013
November 23, 2013
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Consciousness status
Consciousness status is evaluated by the observer's assessment of alertness and sedation score (OAA/S).
Participants will be monitored during the period of propofol infusion, an expected average of less than 10 min
Study Arms (2)
PD group
Patients with Parkinson's disease undergoing deep brain stimulator implantation and pulse generator placement
non-PD group
Patients without Parkinson's disease undergoing intracranial surgery
Eligibility Criteria
Our study recruits patients with Parkinson's disease undergoing deep brain stimulator implantation and pulse generator placement under general anesthesia and non-Parkinsonian patients without Parkinson's disease undergoing intracranial surgery under general anesthesia
You may qualify if:
- Patients with Parkinson's disease undergoing deep brain stimulator implantation and pulse generator placement under general anesthesia
- non-Parkinsonian patients without Parkinson's disease undergoing intracranial surgery under general anesthesia
You may not qualify if:
- ASA score higher than Class III
- predicted difficult airway
- hearing impairment
- inability to corporate with instruction
- alcohol or drug abuser
- patients refusing to provide informed consent
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Department of Anesthesiology, Changhai Hospital
Shanghai, Shanghai Municipality, 200433, China
Related Publications (1)
Xu XP, Yu XY, Wu X, Hu XW, Chen JC, Li JB, Wang JF, Deng XM. Propofol requirement for induction of unconsciousness is reduced in patients with Parkinson's disease: a case control study. Biomed Res Int. 2015;2015:953729. doi: 10.1155/2015/953729. Epub 2015 Oct 1.
PMID: 26495319DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Jia-feng Wang, M.D.
Department of Anesthesiology, Changhai Hospital, Second Military Medical University
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Dr.
Study Record Dates
First Submitted
November 19, 2013
First Posted
November 28, 2013
Study Start
January 1, 2012
Primary Completion
June 1, 2013
Study Completion
June 1, 2013
Last Updated
November 28, 2013
Record last verified: 2013-11