Amplitude and Rate of Intrinsic Feedback During Treadmill Training for Parkinson's Disease

NCT01987557 | Completed Results

• 1 other identifier: MDRC
• Study Type: interventional
• Target: 48
• Locations: 0 countries
• Sites: N/A

Brief Summary

Treadmill training has been shown to be beneficial for reducing motor symptoms of Parkinson's disease (PD). The mechanisms for the therapeutic effects of treadmill training remain unknown. However, specific types of intrinsic feedback generated from muscle spindles (detect changes in length of muscle) and golgi tendon organs (detect muscle force) seem to be an important factor for achieving the reductions in motor scores. This study will compare a treadmill program that generates a high rate of intrinsic feedback to a treadmill program focused on generating a high magnitude of intrinsic feedback.

Conditions

Parkinson's Disease; Treadmill

Keywords

treadmill; parkinson's; proprioception; cadence; step length; intrinsic feedback

Outcome Measures

Primary Outcomes (1)

• Motor Section of the Unified Parkinson's Disease Rating Scale (UPDRS-III)

  A measure of the motor symptom severity within Parkinsons. UPDRS III is a qualitative assessment performed by a trained clinician. Specifically, a change in UPDRS III from pre to post is the main outcome measure. The UPDRS-III score is a summation of 27 tasks that are scored from 0-4. 0 meaning no impairment, and 4 representing extreme impairment, inability to complete task. Possible scores on the UPDRS-III range from 0 (no impairment) to 108 (extreme impairment).

  Pre assessments are conducted in the week prior to the treadmill program. Post are conducted during the week immediately following the program. Changes after the 6 week treadmill program are being examined

Secondary Outcomes (2)

• Spatiotemporal Aspects of Gait

  pre test occurs within the week prior to the start of the treadmill training program. Post testing will occur during the week immediately following the 6 week treadmill training program.

• Static Posturography (Balance/Postural Control)

  pre test occurs within the week prior to the start of the treadmill training program. Post testing will occur during the week immediately following the 6 week treadmill training program.

Study Arms (3)

Treadmill Intervention 1: Rate Group

EXPERIMENTAL

Participants in this condition will walk with a cadence (steps per minute) that is approximately 35% faster than comfortable walking pace. In this condition, participants will maintain a step length that is similar to that of their comfortable walking pace.

Behavioral: rate group

Magnitude treadmill group

EXPERIMENTAL

In this condition participants will walk on a treadmill with weights on their ankles to elicit a greater magnitude of instrinsic feedback from force sensitive golgi tendon organs

Behavioral: magnitude treadmill group

regular treadmill walking

PLACEBO COMPARATOR

participants will walk at a comfortable self-selected pace on a treadmill

Behavioral: regular treadmill walking

Interventions

rate group BEHAVIORAL

walking with a high cadence (steps per minute)

Treadmill Intervention 1: Rate Group

magnitude treadmill group BEHAVIORAL

Magnitude treadmill group

regular treadmill walking BEHAVIORAL

regular treadmill walking

Eligibility Criteria

• Age: 40 Years - 79 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• diagnosis of Parkinson's disease
• must be able to walk unassisted for 10 metres

You may not qualify if:

• cardiovascular disease/history of stroke
• Dementia
• lower body injury that would be worsened by repetitive walking

Sponsors & Collaborators

• Wilfrid Laurier University: lead

MeSH Terms

Conditions

Parkinson Disease

Condition Hierarchy (Ancestors)

Parkinsonian Disorders; Basal Ganglia Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Movement Disorders; Synucleinopathies; Neurodegenerative Diseases

Results Point of Contact

• Title: Matthew Lasswell
• Organization: WilfridLU

lass3260@mylaurier.ca

9056992087

Publication Agreements

• PI is Sponsor Employee: Yes

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Mr. Matthew Lasswell

Study Record Dates

• First Submitted: October 9, 2013
• First Posted: November 19, 2013
• Study Start: October 1, 2013
• Primary Completion: August 1, 2014
• Study Completion: August 1, 2014
• Last Updated: June 17, 2015
• Results First Posted: June 17, 2015

Record last verified: 2015-06