NCT01984190

Brief Summary

Venous thromboembolic events (VTE), either deep vein thromboses or pulmonary emboli, are important complications in patients undergoing knee or hip arthroplasty. This multicenter Clinical Registry is aimed at collecting large volume clinical effectiveness data of ActiveCare+S.F.T® mobile compression device +/- aspirin in lowering the potential risk of venous thromboembolism (VTE) prophylaxis in patients undergoing primary lower extremity total joint arthroplasty. The results can then be compared to pharmacology protocols.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
411

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Apr 2011

Shorter than P25 for all trials

Geographic Reach
1 country

10 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

April 1, 2011

Completed
6 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

October 1, 2011

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

October 1, 2011

Completed
2.1 years until next milestone

First Submitted

Initial submission to the registry

November 7, 2013

Completed
7 days until next milestone

First Posted

Study publicly available on registry

November 14, 2013

Completed
Last Updated

September 4, 2014

Status Verified

November 1, 2013

Enrollment Period

6 months

First QC Date

November 7, 2013

Last Update Submit

September 3, 2014

Conditions

Keywords

venous thromboembolismdeep vein thrombosispulmonary embolihip arthroplastyknee arthroplastyefficacymobile compression devicemechanical deviceprophylaxis.

Outcome Measures

Primary Outcomes (1)

  • Incidence of deep venous thrombosis or pulmonary emboli

    Within 3 months post operatively

Study Arms (1)

Lower Extremity Joint Arthroplasty

Postoperative venous thromboembolism incidence in lower extremity joint arthroplasty using only the mobile compression device with or without aspirin for venous thromboembolism prevention. Sub-analysis of Total Hip Arthroplasty and Total Knee Arthroplasty will be included.

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

The registry will include all Adult patients scheduled for elective unilateral total hip arthroplasty (THA) or total knee arthroplasty (TKA), or unicondylar knee arthroplasty (UKA), where the orthopaedic surgeon is using the ActiveCare+S.F.T® mobile compression device as a monotherapy for venous thromboembolism prevention.

You may qualify if:

  • Adult patients (Age \>18 yrs).
  • Patient intended to undergo elective primary unilateral total hip arthroplasty (THA) or total knee arthroplasty (TKA), or unicondylar knee arthroplasty (UKA).
  • Patient is using only ActiveCare+S.F.T® +/- aspirin for venous thromboembolism (VTE) prevention(Aspirin (ASA) can be prescribed at the discretion of the surgeon).

You may not qualify if:

  • Patient with known coagulation disorder
  • Patient currently treated with anticoagulant medications.
  • Patients with current signs and symptoms of or history of deep vein thrombosis(DVT) or pulmonary embolism (PE).
  • Patients currently suffering from a solid tumor malignancy.
  • Patients who underwent major surgery procedure within 3 months prior to participation in the registry

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (10)

Arkansas Specialty Orthopaedics

Little Rock, Alaska, 72205, United States

Location

Shiley Center for Orthopaedic Research and Education at Scripps Clinic

La Jolla, California, 92037, United States

Location

VA Palo Alto Health Care System

Menlo Park, California, 94025, United States

Location

Rubin Institute for Advanced Orthopedics,

Baltimore, Maryland, 21215, United States

Location

Twin Cities Orthopaedics

Edina, Minnesota, 55435, United States

Location

Washington University School of Medicine, Department of Orthopaedic Surgery

St Louis, Missouri, 63310, United States

Location

Hospital for Special Surgery

New York, New York, 10021, United States

Location

Cleveland Clinic

Cleveland, Ohio, 44195, United States

Location

The Center Orthopedic & Neurosurgical Care &Research

Bend, Oregon, 97710, United States

Location

Anderson Orthopaedic Clinic

Alexandria, Virginia, 22306, United States

Location

Related Publications (2)

  • Colwell CW Jr, Froimson MI, Mont MA, Ritter MA, Trousdale RT, Buehler KC, Spitzer A, Donaldson TK, Padgett DE. Thrombosis prevention after total hip arthroplasty: a prospective, randomized trial comparing a mobile compression device with low-molecular-weight heparin. J Bone Joint Surg Am. 2010 Mar;92(3):527-35. doi: 10.2106/JBJS.I.00047.

    PMID: 20194309BACKGROUND
  • Colwell CW Jr, Froimson MI, Anseth SD, Giori NJ, Hamilton WG, Barrack RL, Buehler KC, Mont MA, Padgett DE, Pulido PA, Barnes CL. A mobile compression device for thrombosis prevention in hip and knee arthroplasty. J Bone Joint Surg Am. 2014 Feb 5;96(3):177-83. doi: 10.2106/JBJS.L.01031.

MeSH Terms

Conditions

Venous ThromboembolismVenous ThrombosisPulmonary Embolism

Condition Hierarchy (Ancestors)

ThromboembolismEmbolism and ThrombosisVascular DiseasesCardiovascular DiseasesThrombosisLung DiseasesRespiratory Tract DiseasesEmbolism

Study Officials

  • Clifford W Colwell, Jr., MD

    Shiley Center for Orthopaedic Research and Education at Scripps Clinic

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Target Duration
3 Months
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

November 7, 2013

First Posted

November 14, 2013

Study Start

April 1, 2011

Primary Completion

October 1, 2011

Study Completion

October 1, 2011

Last Updated

September 4, 2014

Record last verified: 2013-11

Locations