Study of the Preservation of the Left Colic Artery on Rectum Cancer Surgery

NCT01979029 | Completed Results

• 1 other identifier: Left Colic Artery
• Study Type: interventional
• Target: 57
• Locations: 1 country
• Sites: 1

Brief Summary

To evaluate the influence to the blood supply of the anastomosis and the harvest of the No. 253 lymph nodes in different surgical methods--- preserving the left colic artery (LCA) and resect the No. 253 lymph node specifically in the radical resection of rectal carcinoma or dividing at the root of the inferior mesenteric artery (IMA) in the radical resection of rectal carcinoma.

Conditions

Rectum Cancer

Outcome Measures

Primary Outcomes (1)

• The Blood Pressure of the Arterial Arcade

  after ligating the inferior mesentric artery or superior rectal artery

Secondary Outcomes (1)

• Distal Colon Length

  after digestive tract reconstruction

Other Outcomes (1)

• Systemic Blood Pressure

  after ligating the inferior mesentric artery and measuring the blood pressure of the marginal artery of distal colon

Study Arms (2)

preserving the left colic artery

EXPERIMENTAL

We preserve the left colic artery and resect the No. 253 lymph node during the rectal surgery.

Procedure: preserving the left colic artery

not preserving the left colic artery

EXPERIMENTAL

We preserve the high ligation of the inferior mesenteric artery during the rectal surgery.

Procedure: not preserving the left colic artery

Interventions

preserving the left colic artery PROCEDURE

The root of the inferior mesenteric artery(IMA) was carefully dissected and the artery wall was exposed all the way to the bifurcation of the left colic artery(LCA) and the superior rectal artery (SRA), exposing the LCA from its root until the inferior mesenteric vein (IMV) was recognized. Subsequently, dissection was continued along the IMV up to the level of the root of the IMA. Then the sigmoid mesentery was transected from the root of the IMA to the IMV, and the IMV and the root of the SRA were ligated. Finally, the adipose tissue with the lymph nodes in the area surrounded by the IMA, IMV, and LCA was dissected, with preservation of the LCA .

preserving the left colic artery

not preserving the left colic artery PROCEDURE

The root of the IMA was exposed and the fatty tissue around the root of the IMA was swept in order to maximize the lymph node retrieval rate. Subsequently, the IMA was ligated 1 cm from the aorta to avoid damaging the nerves.

not preserving the left colic artery

Eligibility Criteria

• Age: 18 Years - 85 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients coming to FirstJilinU diagnosed rectum cancer by endoscopy and pathology.
• The rectum cancer is the first malignant neoplasm the patient has got.
• The cancer is solitary, and is 3cm to 20cm to the anus.
• The surgical method is limited to Dixon.

You may not qualify if:

• Being in the acute phase of inflammation before operation and emergency surgery.
• Patients receiving steroid medication or preoperative radiotherapy。
• Discovering macrometastasis before or in the operation.
• The rectum cancer that can't be radical resected.

Sponsors & Collaborators

• Jian Suo: lead

Study Sites (1)

First Hospital of Jilin University

Changchun, Jilin, 130021, China

Location

MeSH Terms

Conditions

Rectal Neoplasms

Condition Hierarchy (Ancestors)

Colorectal Neoplasms; Intestinal Neoplasms; Gastrointestinal Neoplasms; Digestive System Neoplasms; Neoplasms by Site; Neoplasms; Digestive System Diseases; Gastrointestinal Diseases; Intestinal Diseases; Rectal Diseases

Results Point of Contact

• Title: Jian Suo
• Organization: First Hospital of Jilin University

suojian42@hotmail.com

0431-88785605

Study Officials

• Jian Suo, Dr.

  Department of Gastrointestinal Surgery, First Hospital of Jilin University, Changchun, China.

  STUDY CHAIR

Publication Agreements

• PI is Sponsor Employee: Yes

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Headmaster, Dept.of General Surgery

Study Record Dates

• First Submitted: October 25, 2013
• First Posted: November 8, 2013
• Study Start: February 1, 2013
• Primary Completion: September 1, 2014
• Study Completion: October 1, 2014
• Last Updated: June 6, 2016
• Results First Posted: June 6, 2016

Record last verified: 2016-04

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)