Stem Cell Therapy for Cerebral Palsy
Open Label Study of Autologous Bone Marrow Mononuclear Cells in Cerebral Palsy
1 other identifier
interventional
N/A
1 country
1
Brief Summary
the purpose of this study was to study the effect of stem cell therapy on common symptoms of cerebral palsy patients.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
Started Aug 2010
Typical duration for phase_1
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
August 1, 2010
CompletedPrimary Completion
Last participant's last visit for primary outcome
August 1, 2013
CompletedStudy Completion
Last participant's last visit for all outcomes
August 1, 2013
CompletedFirst Submitted
Initial submission to the registry
October 25, 2013
CompletedFirst Posted
Study publicly available on registry
November 8, 2013
CompletedOctober 25, 2018
October 1, 2018
3 years
October 25, 2013
October 23, 2018
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Change in clinical symptoms of cerebral palsy after 6 months
Six months
Study Arms (1)
stem cell
EXPERIMENTALautologous bone marrow mononuclear cell transplantation
Interventions
Eligibility Criteria
You may qualify if:
- Diagnosed cases of any type of Cerebral Palsy
- age above 12 months.
You may not qualify if:
- presence of acute infections such as Human immunodeficiency virus/Hepatitis B Virus/Hepatitis C Virus
- malignancies
- bleeding tendencies
- pneumonia
- renal failure
- severe liver dysfunction
- severe anemia \[Hemoglobin \< 8\]
- any bone marrow disorder
- space occupying lesion in brain
- other acute medical conditions such as respiratory infection and pyrexia.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Neurogen brain and spine institute
Mumbai, Maharashtra, 400071, India
Related Publications (4)
Li Y, Tu L, Chen D, Jiang R, Wang Y, Wang S. [Study on functional recovery of hypoxic-ischemic brain injury by Rg1-induced NSCs]. Zhongguo Zhong Yao Za Zhi. 2012 Feb;37(4):509-14. Chinese.
PMID: 22667154BACKGROUNDSharma A, Sane H, Paranjape A, Gokulchandran N, Kulkarni P, Nagrajan A, Badhe P. Positron emission tomography-computer tomography scan used as a monitoring tool following cellular therapy in cerebral palsy and mental retardation-a case report. Case Rep Neurol Med. 2013;2013:141983. doi: 10.1155/2013/141983. Epub 2013 Feb 3.
PMID: 23431488BACKGROUNDWang X, Cheng H, Hua R, Yang J, Dai G, Zhang Z, Wang R, Qin C, An Y. Effects of bone marrow mesenchymal stromal cells on gross motor function measure scores of children with cerebral palsy: a preliminary clinical study. Cytotherapy. 2013 Dec;15(12):1549-62. doi: 10.1016/j.jcyt.2013.06.001. Epub 2013 Oct 5.
PMID: 24100132BACKGROUNDAlvarez P, Carrillo E, Velez C, Hita-Contreras F, Martinez-Amat A, Rodriguez-Serrano F, Boulaiz H, Ortiz R, Melguizo C, Prados J, Aranega A. Regulatory systems in bone marrow for hematopoietic stem/progenitor cells mobilization and homing. Biomed Res Int. 2013;2013:312656. doi: 10.1155/2013/312656. Epub 2013 Jun 17.
PMID: 23844360BACKGROUND
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- interventional
- Phase
- phase 1
- Allocation
- NA
- Masking
- NONE
- Purpose
- TREATMENT
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
October 25, 2013
First Posted
November 8, 2013
Study Start
August 1, 2010
Primary Completion
August 1, 2013
Study Completion
August 1, 2013
Last Updated
October 25, 2018
Record last verified: 2018-10