Dynamic Preload Parameters During Liver Transplantation

NCT01971333 | Unknown

• 1 other identifier: 201309024RIND
• Study Type: observational
• Target: 80
• Locations: 1 country
• Sites: 1

Brief Summary

The arterial system compliance is compromised in liver cirrhotic patients. Dynamic preload variables are either pressure-based (e.g.pulse pressure variation; PPV), flow-based (e.g. stroke volume variation; SVV), or volume-based (plethysmographic variability index; PVI). It is not yet clear that dynamic preload parameters based on which mechanism will be accurate to predict fluid responsiveness in the cirrhotic patients. Therefore, this study aimed to claried which dynamic preload parameters would be more accurate during the liver transplantation.

Conditions

Liver Cirrhosis

Keywords

pulse pressure variation; stroke volume variation; plethysmographic variation index; fluid responsiveness

Outcome Measures

Primary Outcomes (1)

• Change of cardiac index after fluid loading

  one day

Secondary Outcomes (3)

• Fluid responsiveness parameters: pulse pressure variation

  one day

• Fluid responsiveness parameters: stroke volume variation

  one day

• Fluid responsiveness parameters: plethysmographic variation index

  one day

Other Outcomes (3)

• Mean arterial pressure changes

  one day

• Central venous pressure changes

  one day

• Heart rate changes

  one day

Study Arms (1)

Liver transplantation

Compare intraoperative change of dynamic parameters after fluid loading: 1. pulse pressure variation 2. stroke volume variation 3. plethysmographic variation index

Eligibility Criteria

• Age: 6 Months - 75 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

End stage liver disease patients scheduled for liver transplantation in National Taiwan University Hospital

You may qualify if:

• End stage liver disease patients scheduled for liver transplantation in National Taiwan University Hospital

You may not qualify if:

• Allergic reaction
• preexisting arrythmia

Sponsors & Collaborators

• National Taiwan University Hospital: lead

Study Sites (1)

Department of Anesthesiology, NTUH, Taipei, Taiwan

Taipei, Taiwan

RECRUITING

Related Publications (2)

• Vos JJ, Kalmar AF, Struys MM, Wietasch JK, Hendriks HG, Scheeren TW. Comparison of arterial pressure and plethysmographic waveform-based dynamic preload variables in assessing fluid responsiveness and dynamic arterial tone in patients undergoing major hepatic resection. Br J Anaesth. 2013 Jun;110(6):940-6. doi: 10.1093/bja/aes508. Epub 2013 Jan 24.

  PMID: 23348202 BACKGROUND

• Wu CY, Cheng YJ, Liu YJ, Wu TT, Chien CT, Chan KC; NTUH Center of Microcirculation Medical Research (NCMMR). Predicting stroke volume and arterial pressure fluid responsiveness in liver cirrhosis patients using dynamic preload variables: A prospective study of diagnostic accuracy. Eur J Anaesthesiol. 2016 Sep;33(9):645-52. doi: 10.1097/EJA.0000000000000479.

  PMID: 27167058 DERIVED

MeSH Terms

Conditions

Liver Cirrhosis

Condition Hierarchy (Ancestors)

Liver Diseases; Digestive System Diseases; Fibrosis; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Chun Yu Wu, M.D.

  Department of Anesthesiology, National Taiwan University Hospital

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Chun Yu Wu, M.D.

CONTACT

+886-2-23123456; longersolo@gmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: October 23, 2013
• First Posted: October 29, 2013
• Study Start: October 1, 2013
• Primary Completion: October 1, 2014
• Study Completion: October 1, 2014
• Last Updated: October 30, 2013

Record last verified: 2013-10

Locations

TW (1)