NCT01970631

Brief Summary

The objectives of this research are to conduct a proof of concept randomized controlled trial with 200 patients undergoing primary total knee replacement (TKR) at Brigham and Women's Hospital (BWH). The trial will compare levels of physical activity in subjects in the behavioral and economic interventions versus "Usual Care" post TKR.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
202

participants targeted

Target at P75+ for not_applicable

Timeline
Completed

Started Jan 2014

Typical duration for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

October 23, 2013

Completed
5 days until next milestone

First Posted

Study publicly available on registry

October 28, 2013

Completed
2 months until next milestone

Study Start

First participant enrolled

January 9, 2014

Completed
2.8 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

November 5, 2016

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

November 5, 2016

Completed
Last Updated

January 18, 2018

Status Verified

January 1, 2018

Enrollment Period

2.8 years

First QC Date

October 23, 2013

Last Update Submit

January 16, 2018

Conditions

Keywords

OsteoarthritisTotal Knee Replacementtotal Knee ArthroplastyPost-operative recovery TKRPhysical ActivityMotivational InterviewingFinancial Incentives

Outcome Measures

Primary Outcomes (1)

  • number of steps

    The primary outcome is the average number of steps over 7 days as measured by accelerometer at 6 months post-TKR.

    6 months

Secondary Outcomes (1)

  • Adherence to PA guidelines

    6-months

Study Arms (4)

Usual Care

NO INTERVENTION

Participants randomized to the Usual Care group will receive the current standard post-operative TKR care.

Motivational Interviewing (MI)

ACTIVE COMPARATOR

Participants randomized to the MI Intervention group will receive up to 14 telephone calls from a Health Educator for 9 months post-TKR.

Behavioral: Motivational Interviewing (MI)

Financial Incentives (FI)

ACTIVE COMPARATOR

Participants randomized to the FI Intervention group will receive financial incentives for completing physical activity logs weekly/bi-weekly and achieving pre-specified physical activity goals over the course of the study.

Other: Financial Incentives

Motivational Inverterviewing (MI) + Financial Incentives (FI)

ACTIVE COMPARATOR

Participants randomized to the FI + MI Intervention group will receive financial incentives for completing physical activity logs weekly/bi-weekly and achieving pre-specified physical activity goals as well as receive up to 14 telephone calls from a Health Educator for 9 months post-TKR.

Behavioral: Motivational Interviewing (MI)Other: Financial Incentives

Interventions

The motivational interviewing arms of SPARKS will consist of Health Educators trained in Motivational Interviewing (MI) techniques contacting participants at regular intervals over the course of the nine months following participants' total knee replacement (TKR).

Motivational Interviewing (MI)Motivational Inverterviewing (MI) + Financial Incentives (FI)

The financial intervention arms of SPARKS will provide compensation to participants for completing physical activity logs weekly/bi-weekly and reaching pre-specified physical activity goals.

Financial Incentives (FI)Motivational Inverterviewing (MI) + Financial Incentives (FI)

Eligibility Criteria

Age40 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Scheduled to undergo primary TKA at BWH
  • Osteoarthritis is the principal underlying diagnosis
  • Age \>=40 at the projected date of TKA
  • English-speaking
  • Willing and able to access the internet to complete study related questionnaires

You may not qualify if:

  • Osteoarthritis is not the principal underlying diagnosis (e.g. inflammatory arthritis)
  • Dementia (can not fill out forms)
  • Psychological issues that preclude participation, as identified by participating surgeons
  • Does not have access to a computer and/or the internet.
  • Non-English speaker (instruments are not validated in Spanish); very few non-English speakers (\<5%) are otherwise eligible
  • Age \<40 at the projected date of TKA (TKA is usually due to major trauma, juvenile onset or congenital disease)
  • Lives in a nursing home (difficult to track costs)
  • Implantation of Unicompartamental Knee Arthroscopy (different clinical features and different costs)
  • Bilateral TKA in same admission (simultaneous), staged or within 6 months
  • Uses a wheelchair or walker to ambulate
  • Has been told by a physician that he/she has a heart condition and should only do physical activity recommended by a doctor
  • Has pain in his/her chest when doing physical activity
  • Loses balance because of dizziness
  • Loses consciousness
  • Unable/unwilling to wear Fitbit® accelerometer for 5 or more days during baseline visit

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Brigham and Women's Hospital

Boston, Massachusetts, 02115, United States

Location

Related Publications (2)

  • Losina E, Collins JE, Deshpande BR, Smith SR, Michl GL, Usiskin IM, Klara KM, Winter AR, Yang HY, Selzer F, Katz JN. Financial Incentives and Health Coaching to Improve Physical Activity Following Total Knee Replacement: A Randomized Controlled Trial. Arthritis Care Res (Hoboken). 2018 May;70(5):732-740. doi: 10.1002/acr.23324. Epub 2018 Apr 12.

  • Usiskin IM, Yang HY, Deshpande BR, Collins JE, Michl GL, Smith SR, Klara KM, Selzer F, Katz JN, Losina E. Association between activity limitations and pain in patients scheduled for total knee arthroplasty. BMC Musculoskelet Disord. 2016 Sep 1;17(1):378. doi: 10.1186/s12891-016-1233-2.

MeSH Terms

Conditions

OsteoarthritisJoint DiseasesMotor Activity

Interventions

Motivational Interviewing

Condition Hierarchy (Ancestors)

ArthritisMusculoskeletal DiseasesRheumatic DiseasesBehavior

Intervention Hierarchy (Ancestors)

Directive CounselingCounselingMental Health ServicesBehavioral Disciplines and ActivitiesHealth ServicesHealth Care Facilities Workforce and Services

Study Officials

  • Elena Losina, PhD

    Brigham and Women's Hospital

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
OUTCOMES ASSESSOR
Purpose
SUPPORTIVE CARE
Intervention Model
FACTORIAL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Co-Director, Orthopaedic and Arthritis Center for Outcomes Research

Study Record Dates

First Submitted

October 23, 2013

First Posted

October 28, 2013

Study Start

January 9, 2014

Primary Completion

November 5, 2016

Study Completion

November 5, 2016

Last Updated

January 18, 2018

Record last verified: 2018-01

Locations