The Effect of Chronic Anemia on Safety Period of Tracheal Intubation in Gynecology Patients
1 other identifier
interventional
45
1 country
1
Brief Summary
- 1.Every individual receiving a general anesthetic is at potential risk for developing a ''cannot intubate-cannot ventilate'' situation following anesthetic induction.
- 2.Building up of oxygen reserves assumes great significance as this provides a longer duration of non-hypoxic apnea should one be faced with an unanticipated difficult airway.
- 3.The main physiological functions of red blood cell hemoglobin are to deliver oxygen to the peripheral tissues.
- 4.During anemia, a reduction in blood oxygen content occurs as a result of reduced Hb while arterial oxygenation and oxyhemoglobin saturation remain high.
- 5.Previous studies about the duration of non-hypoxic apnoea focus on methods to improve the safety period of tracheal intubation.
- 6.To our knowledge, there is no literature about the duration of non-hypoxic apnoea of anemia patients.
- 7.The aim of this study was to assess the effect of chronic anemia on the duration of non-hypoxic apnoea during induction of anaesthesia.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable
Started Apr 2013
Shorter than P25 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
April 1, 2013
CompletedPrimary Completion
Last participant's last visit for primary outcome
September 1, 2013
CompletedStudy Completion
Last participant's last visit for all outcomes
September 1, 2013
CompletedFirst Submitted
Initial submission to the registry
October 12, 2013
CompletedFirst Posted
Study publicly available on registry
October 24, 2013
CompletedOctober 24, 2013
October 1, 2013
5 months
October 12, 2013
October 18, 2013
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
duration of non-hypoxic apnoea
up to 6 months
Study Arms (3)
Group A
EXPERIMENTALthe hemoglobin is \>12g/L in patients from group A.
Group B
EXPERIMENTALHb 9-12g/L
Group C
EXPERIMENTALHb\<9g/L
Interventions
Eligibility Criteria
You may qualify if:
- patients scheduled to undergo general anesthesia
- American Society of Anesthesiologists Performance Status 1-2
- adults
You may not qualify if:
- Individuals with significant cardiorespiratory or cerebrovascular disease,
- difficult intubation
- history of epilepsy
- body mass index \>25 kg/m2,
- and those who had smoking history in past 6 months
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Fudan Universitylead
Study Sites (1)
Fudan university
Shanghai, Shanghai Municipality, 200090, China
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY DIRECTOR
Guiqi Geng, PhD
Department of anesthesiology, obstetrics and genecology hospital, FuDan university
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- HEALTH SERVICES RESEARCH
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- PhD
Study Record Dates
First Submitted
October 12, 2013
First Posted
October 24, 2013
Study Start
April 1, 2013
Primary Completion
September 1, 2013
Study Completion
September 1, 2013
Last Updated
October 24, 2013
Record last verified: 2013-10