Prognosis Scoring System for Acute-on-Chronic Liver Failure

NCT01961440 | Unknown

• 1 other identifier: zssywzb02
• Study Type: observational
• Target: 1,000
• Locations: 0 countries
• Sites: N/A

Brief Summary

This research is to establish a simple and practical system to predict the prognosis of sever hepatitis B.Seven factors (level of serum total bilirubin, prothrombin time, severity of hepatic encephalopathy, hepatorenal syndrome,ascites ,infection and size of liver) which were easier to evaluate and more influential， were included to establish a prognosis scoring system．The scorings of a new score system and MELD were graded at the same time in the patients with sever hepatitis B. And then the distribution figures of survival rates and mortality rates were done according to the scores from low to high. The features of distribution figures of two score system in survival rates and mortality rates and significances of clinical application in certain score were interpreted.

Conditions

Liver Failure

Outcome Measures

Primary Outcomes (1)

• survival rate

  twelve weeks

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)
• Sampling Method: Probability Sample

Study Population

The population from large hospitals will be selected.

You may qualify if:

• serum hepatitis B surface antigen(HBsAg) positive for at least 6 months;
• All patients had a poor general condition, manifested as general malaise, fatigue, jaundice and so on;
• serum T-Bil of 171 mmol/L or more; or serum T-Bil rises 17.1 mmol/L or more per day;

You may not qualify if:

• superinfection or co-infection with hepatitis A, C, D, E, cytomegalovirus and HIV, or Epstein-Barr virus;
• other liver diseases such as alcoholic liver disease, drug-induced hepatitis, Wilson disease and autoimmune hepatitis;
• ascites or gastrointestinal bleeding or peptic ulcer or esophageal varix by electronic gastroscope examination;
• decompensated liver cirrhosis;
• severe bacterial or fungal infections;
• a history of diabetes or cardiac disease or hypertension or nephrosis.

Sponsors & Collaborators

• Third Affiliated Hospital, Sun Yat-Sen University: lead

MeSH Terms

Conditions

Liver Failure

Condition Hierarchy (Ancestors)

Hepatic Insufficiency; Liver Diseases; Digestive System Diseases

Central Study Contacts

zhe-bin wu

CONTACT

13751743264; wzbice1982@sohu.com

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: October 9, 2013
• First Posted: October 11, 2013
• Study Start: October 1, 2013
• Primary Completion: December 1, 2014
• Last Updated: October 11, 2013

Record last verified: 2013-09