The Effects of L-Arabinose and D-xylose on Intestinal Sucrase Activity in Man

NCT01957098 | Completed

• 1 other identifier: (KF) 11 324909
• Study Type: interventional
• Target: 14
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to investigate the effect of L-arabinose and D-xylose in a sugar-rich drink on intestinal sucrase activity in healthy volunteers by measuring postprandial blood glucose and insulin, and selected intestinal hormonal responses to increasing doses of L-arabinose and D-xylose.

Conditions

Insulin Resistance

Keywords

L-arabinose; D-xylose; sucrose; glucose; insulin; C-peptide; GLP-1

Outcome Measures

Primary Outcomes (1)

• Blood glucose, insulin, C-peptide and GLP-1

  Level of glucose, insulin, C-peptide and glucagon-like peptide-1 (GLP-1) over time, the area under the curve (AUC), the peak value and time to peak

  -15, 0, 15, 30, 45, 60, 90, 120, 180 min

Secondary Outcomes (1)

• Appetite measurements and energy intake

  -15, 30, 60, 90, 120, 150 and 180 min

Study Arms (4)

0% pentose

PLACEBO COMPARATOR

Pure sucrose without pentoses added.

Dietary Supplement: Placebo comparator: 0% pentose

4% D-xylose

ACTIVE COMPARATOR

Sucrose drink supplemented with 4% D-xylose

Dietary Supplement: Active comparator: 4% D-xylose

8% D-xylose

ACTIVE COMPARATOR

Sucrose drink supplemented with 8% D-xylose

Dietary Supplement: Active comparator: 8% D-xylose

8% L-arabinose

ACTIVE COMPARATOR

Sucrose drink supplemented with 8% L-arabinose

Dietary Supplement: Active comparator: 8% L-arabinose

Interventions

Placebo comparator: 0% pentose DIETARY_SUPPLEMENT

14 healthy subjects participated in a randomized double-blinded cross-over study based on four single tests. Sucrose containing drinks were supplemented with two different doses of D-xylose and in addition one dose of L-arabinose was included for comparison with earlier studies. Blood was collected fasting and for 3-h postprandially. Appetite sensations and energy intake were registered. Gastrointestinal symptoms were monitored for 24 hours

0% pentose

Active comparator: 4% D-xylose DIETARY_SUPPLEMENT

4% D-xylose

Active comparator: 8% D-xylose DIETARY_SUPPLEMENT

8% D-xylose

Active comparator: 8% L-arabinose DIETARY_SUPPLEMENT

8% L-arabinose

Eligibility Criteria

• Age: 18 Years - 30 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• healthy males
• BMI between 18.4-25 kg/m2
• age between 18 and 30

You may not qualify if:

• donation of blood 3 months before or during the study
• gastrointestinal disorders, diabetes, hypertension, hyperlipidemia, chronic infectious disease (HIV or hepatitis)
• smoking
• consumption of more than 21 alcoholic drinks/week
• elite athletes
• on medication

Sponsors & Collaborators

• University of Copenhagen: lead
• Danisco: collaborator

Study Sites (1)

Institute of Human Nutrition, The Royal Veterinary and Agricultural University

Frederiksberg, DK-1958, Denmark

Location

MeSH Terms

Conditions

Insulin Resistance

Interventions

Pentoses; Xylose; Arabinose

Condition Hierarchy (Ancestors)

Hyperinsulinism; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases

Intervention Hierarchy (Ancestors)

Monosaccharides; Sugars; Carbohydrates

Study Officials

• Jens R Andersen, MD,MPA

  University of Copenhagen

  STUDY CHAIR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, CARE PROVIDER
• Purpose: PREVENTION
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: August 8, 2013
• First Posted: October 8, 2013
• Study Start: October 1, 2006
• Primary Completion: January 1, 2007
• Study Completion: May 1, 2007
• Last Updated: October 8, 2013

Record last verified: 2013-10

Locations

DK (1)