NCT01953653

Brief Summary

This protocol explores the feasibility and acceptability of using two daily diary methods to analyze state-dependent variables and psychosocial health outcomes in Human Immunodeficiency Virus (HIV)-positive young men who have sex with men (YMSM). The study will explore the potential of diaries for use in feedback-based interventions.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
67

participants targeted

Target at P50-P75 for not_applicable

Timeline
Completed

Started Feb 2013

Geographic Reach
1 country

3 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

January 19, 2013

Completed
13 days until next milestone

Study Start

First participant enrolled

February 1, 2013

Completed
8 months until next milestone

First Posted

Study publicly available on registry

October 1, 2013

Completed
4 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

February 1, 2014

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

February 1, 2014

Completed
Last Updated

February 28, 2017

Status Verified

March 1, 2016

Enrollment Period

1 year

First QC Date

January 19, 2013

Last Update Submit

February 27, 2017

Conditions

Outcome Measures

Primary Outcomes (3)

  • Number of Participants who Complete the 66-Day Structured Daily Diary

    The first primary objective of this study is to implement a 66-day structured daily diary with 90 HIV-positive YMSM to explore relationships among daily mood, stressful events, social support, substance use, sexual behavior, and adherence to ART among youth who are currently prescribed to take medication.

    66 days

  • Rate of Completion of 66-Day Structured Daily Diary by Modality Type

    The second primary objective is to explore the feasibility and acceptability of using two daily diary modalities (IVR and IWR) as (1) a novel method of data collection in research involving HIV-positive YMSM, and (2) a potential tool to provide personalized feedback and/or assist with self-monitoring among HIV-positive YMSM.

    66 days

  • Reasons and Rate of for Non-completion of 66-Day Structured Daily Diary

    The second primary objective is to explore the feasibility and acceptability of using two daily diary modalities (IVR and IWR) as (1) a novel method of data collection in research involving HIV-positive YMSM, and (2) a potential tool to provide personalized feedback and/or assist with self-monitoring among HIV-positive YMSM.

    66 days

Secondary Outcomes (1)

  • Participant Responses to how Diary can Provide Personalized Feedback on Triggers to Risk Behaviors

    66 days

Study Arms (2)

A: Begin with Interactive Voice Response (IVR) System

OTHER

Group A participants are randomized the IVR system as Modality #1. After 33 days of diary completion using IVR, they switch to the interactive web response system (IWR)as Modality #2.

Behavioral: Structured daily diary

B: Begin with Interactive Web Response (IWR) System

OTHER

Group B participants are randomized to the IWR system as Modality #1. After 33 days of diary completion using IWR, they switch to the interactive voice response (IVR)system as Modality #2.

Behavioral: Structured daily diary

Interventions

The intervention is a structured daily diary to describe fluctuations in key psychological and behavioral variables impacting daily risk behavior among HIV-positive young men who have sex with men (YMSM), aged 16 to 24 years old who engage in substance use and sexual risk behaviors.

A: Begin with Interactive Voice Response (IVR) SystemB: Begin with Interactive Web Response (IWR) System

Eligibility Criteria

Age16 Years - 24 Years
Sexmale
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64)

You may qualify if:

  • Receives services at one of the selected Adolescent Medicine Trial Unit (AMTU) sites;
  • HIV-1 infection as documented in the participant's medical record by at least one of the following criteria:
  • Reactive HIV screening test result with an antibody-based, Food and Drug Administration (FDA)-licensed assay followed by a positive supplemental assay (e.g., HIV-1 Western Blot, HIV-1 indirect immunofluorescence);
  • Positive HIV-1 deoxyribonucleic acid (DNA) polymerase chain reaction (PCR) assay;
  • Plasma HIV-1 quantitative ribonucleic acid (RNA) assay \>1,000 copies/mL; or
  • Positive plasma HIV-1 RNA qualitative assay
  • Between the ages of 16-24 years, inclusive, at the time of screening;
  • Born biologically male and self-identifies as male at the time of screening;
  • HIV-infected through sexual behavior;
  • At least one self-reported sexual encounter with another man involving oral or anal sex in the past 12 months prior to screening;
  • At least one self-reported episode of unprotected vaginal or anal intercourse within the past 90 days prior to screening and/or substance use, defined as at least one occasion in which four or more alcoholic beverages were consumed and/or two or more occasions of illicit drug use, in the past 90 days, as assessed by the Assessment of Substance Use and Sexual Behavior questionnaire (CRF (F107));
  • Has active cell phone service; is able to access his cell phone seven days a week between 6:00 PM and 6:00 AM the next morning; and is willing and able to use approximately 10 minutes of talk time and receive two text messages per day;
  • Consistent internet access seven days a week between 6:00 PM and 6:00 AM the next morning;
  • Ability to understand, read, and speak English;
  • Ability to read at a fifth grade level, as assessed by the Rapid Estimate of Adolescent Literacy in Medicine (REALM)-TEEN; and
  • +1 more criteria

You may not qualify if:

  • HIV infected via modes other than sexual behavior (e.g., perinatally, via shared needles, or blood transfusion, etc.);
  • Previously enrolled in Adolescent Trials Network (ATN) 112;
  • Active psychiatric condition that in the opinion of the site Principal Investigator (PI) or designee would interfere with the ability to give true informed consent and to adhere to the study requirements;
  • Visibly distraught and/or visibly emotionally unstable (e.g., exhibiting suicidal, homicidal, impulsive or violent behavior);
  • Active drug or alcohol use or dependence that, in the opinion of the site personnel, would interfere with the ability to give true informed consent and to adhere to the study requirements;
  • Acute illness that, in the opinion of the treating clinician, would interfere with the participant's ability to adhere to the protocol requirements and/or interfere with the protocol objectives.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (3)

Children's Hospital of Denver

Aurora, Colorado, 80045, United States

Location

Wayne State University

Detroit, Michigan, 48201, United States

Location

Childrens Hospital of Philadelphia

Philadelphia, Pennsylvania, 19104, United States

Location

Related Links

MeSH Terms

Conditions

HIV Infections

Condition Hierarchy (Ancestors)

Blood-Borne InfectionsCommunicable DiseasesInfectionsSexually Transmitted Diseases, ViralSexually Transmitted DiseasesLentivirus InfectionsRetroviridae InfectionsRNA Virus InfectionsVirus DiseasesGenital DiseasesUrogenital DiseasesImmunologic Deficiency SyndromesImmune System Diseases

Study Officials

  • Patrick Wilson, PhD

    Columbia University

    STUDY CHAIR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NON RANDOMIZED
Masking
NONE
Purpose
SUPPORTIVE CARE
Intervention Model
CROSSOVER
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

January 19, 2013

First Posted

October 1, 2013

Study Start

February 1, 2013

Primary Completion

February 1, 2014

Study Completion

February 1, 2014

Last Updated

February 28, 2017

Record last verified: 2016-03

Locations