The Influence of Polycystic Ovairan Syndrome on Embryonic Developmental Timing

NCT01953146 | Completed

• 1 other identifier: PCOS_time-lapse
• Study Type: observational
• Target: 240
• Locations: 1 country
• Sites: 1

Brief Summary

Polycystic ovary syndrome is one of the most common causes of female infertility. The cause of infertility in PCOS is unknown. Factors other than anovulation, including inherited or induced changes in the embryo quality have been suggested. Time-lapse analysis of embryo development is a sensitive method of detecting reduced embryo viability. Yet, there are no data regarding the embryo development in PCOS assessed by time-lapse analysis.

Conditions

Polycystic Ovarian Disease

Keywords

PCOS

Outcome Measures

Primary Outcomes (1)

• Embryonic developmental timing assessed by Time-lapse analysis

  Embryos were cultured in a time-lapse incubator until arrest or removal at day 6. The time-point of an event was annotated and analyzed for the embryos in focus (in order of appearance).The influence of PCOS on embryo developmental timing was tested in regression models for patient-clustered data

  From fertilization until transfer at day 6

Study Arms (1)

PCOS criteria

nfertile patients undergoing assisted reproduction were consecutively recruited at the Fertility Clinic, Arhus University Hospital from February 2011 to May 2013. Women aged \< 38 years without endometriosis where more than \> 8 oocytes were retrieved were eligible. Patients were categorized in PCOS and non-PCOS according to the Rotterdam criteria for PCOS, defined by the presence of anovulation and polycystic ovaries.

Eligibility Criteria

• Age: 18 Years - 38 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

A consecutive cohort of 249 infertile women attending In vitro fertilization (IVF) or Intra-cytoplasmic sperm injection (ICSI) treatment at the Fertility Clinic, Arhus University Hospital from February 2011 to May 2013.

You may qualify if:

• Women aged \< 38 years without endometriosis and with more than \> 8 oocytes retrieved were eligible. -

You may not qualify if:

• All embryos with more or less than 2 pronuclei, and that did not undergo first cleavage were excluded

Sponsors & Collaborators

• University of Aarhus: lead

Study Sites (1)

Fertility Clinic

Aarhus, N, 8200, Denmark

Location

Related Publications (1)

• Sundvall L, Kirkegaard K, Ingerslev HJ, Knudsen UB. Unaltered timing of embryo development in women with polycystic ovarian syndrome (PCOS): a time-lapse study. J Assist Reprod Genet. 2015 Jul;32(7):1031-42. doi: 10.1007/s10815-015-0488-0. Epub 2015 May 1.

  PMID: 25925351 DERIVED

MeSH Terms

Conditions

Polycystic Ovary Syndrome

Condition Hierarchy (Ancestors)

Ovarian Cysts; Cysts; Neoplasms; Ovarian Diseases; Adnexal Diseases; Genital Diseases, Female; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Genital Diseases; Gonadal Disorders; Endocrine System Diseases

Study Officials

• Ulla B Knudsen, Professor

  Fertility Clinic Aarhus University

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Consultant

Study Record Dates

• First Submitted: September 23, 2013
• First Posted: September 30, 2013
• Study Start: September 1, 2012
• Primary Completion: September 1, 2013
• Study Completion: September 1, 2013
• Last Updated: September 30, 2013

Record last verified: 2013-09

Locations

DK (1)