Impacts of Aldosterone Blockade on Myocardial Remodeling in Hypertensive Patients With Diastolic Failing Heart

NCT01944384 | Completed Phase 4

• 1 other identifier: 200912097M
• Study Type: interventional
• Target: 40
• Locations: 0 countries
• Sites: N/A

Brief Summary

Aim of study: The effects of aldosterone blockade on myocardial remodeling in hypertensive patients with diastolic failing heart remains unclarified. Background: Nearly half of patients with clinical heart failure (HF) have normal left ventricular ejection fraction (LVEF) who usually present with apparent diastolic dysfunction (DD) and are referred as diastolic HF (DHF). The renin-angiotensin-aldosterone system is an established major pathway that is operative in the pathogenesis of HF. The effects of aldosterone on myocardial hypertrophy, fibrosis and endothelial dysfunction have clearly been established in human and animal models. Furthermore, in these models, aldosterone antagonism prevented the development of myocardial fibrosis independent of its effect on blood pressure or myocardial hypertrophy. However, its application to patients with DHF is unspecified. In the study, we hypothesize that aldosterone blockade could reverse LV remodeling process in hypertensive patients with DHF. Study protocol: We will enroll medically well-controlled hypertensive patients who have DHF defined as the presence of exertional dyspnea or HF signs/symptoms, diastolic dysfunction as impaired tissue-Doppler (TDI) derived mitral early annular diastolic velocity (\< 8 cm/s), and LVEF \> 50 % in echocardiography. All patients will be randomized to receive spironolactone 25 mg per day or not for at least 6 months. At baseline before randomization and 6 months after randomization, we will investigate the Quality-of-life (QOL) score by Minnesota Living with Heart Failure questionnaire (Chinese version), echocardiography coupled with TDI to assess the degree of LV hypertrophy, myocardial systolic and diastolic characteristics. Otherwise, we draw blood sampling at baseline and after randomization for quantifying and comparing several biomarkers which are currently proved to be correlated with LV hypertrophy, myocardial fibrosis, and biomechanical stretch in DHF patients, such as N-terminal pro-brain-type natriuretic peptide, matrix metalloproteinase-2, carboxy-terminal telopeptide, procollagen type III amino-terminal propeptide, soluble ST2, and galectin-3. Expected results: Aldosterone antagonism is effective for hypertensive patients with DHF by improving the quality of life, echo-derived myocardial function, and reducing ventricular mechanical stretch through lessening the degree of LV hypertrophy and myocardial fibrosis.

Conditions

Diastolic Heart Failure

Outcome Measures

Primary Outcomes (1)

• peak myocardial velocity (Sm) during the ejection phase over the 6-basal segments

  6 months

Secondary Outcomes (6)

• pro-brain natriuretic peptide (proBNP)

  6 months

• matrix metalloproteinase-2 (MMP-2)

  6 months

• matrix metalloproteinase-9 (MMP-9), etc.

  6 months

• carboxy-terminal telopeptide of collagen I(ICTP)

  6 months

• procollagen type III amino-terminal propeptide (PIIINP)

  6 months

Study Arms (2)

aldactone

EXPERIMENTAL

aldactone 25 mg for 6 months

Drug: aldactone

without aldactone

NO INTERVENTION

Interventions

aldactone DRUG

aldactone 25 mg for 6 months

aldactone

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• well-controlled hypertensive patients with diastolic HF defined as the presence of diastolic dysfunction, normal LVEF (\> 50 %), and exertional dyspnea (≧ New York Heart Association functional class II) or other HF signs/symptoms fulfilled with the Framingham criteria despite optimal pharmacological therapy

You may not qualify if:

• secondary hypertension
• restrictive, constrictive or hypertrophic cardiomyopathy
• more than moderate (mitral or tricuspid regurgitant jet area/atrial area more than 20%; aortic regurgitant jet to the tip of the mitral valve leaflets) valvular heart diseases
• chronic atrial fibrillation
• usage of aldosterone antagonist within 3 months
• chronic pulmonary disease
• myocardial infarction within 3 months or active ischemia needing revascularization
• LVEF less than 50% by echocardiography
• renal failure (serum creatinine concentration more than 2.0 mg/dL).

Sponsors & Collaborators

• National Taiwan University Hospital: lead

MeSH Terms

Conditions

Heart Failure, Diastolic

Interventions

Spironolactone

Condition Hierarchy (Ancestors)

Heart Failure; Heart Diseases; Cardiovascular Diseases

Intervention Hierarchy (Ancestors)

Lactones; Organic Chemicals; Pregnenes; Pregnanes; Steroids; Fused-Ring Compounds; Polycyclic Compounds

Study Officials

• Wang Yi Chih, MD, PhD

  NTUH

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: phase 4
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 4, 2013
• First Posted: September 17, 2013
• Study Start: August 1, 2010
• Primary Completion: December 1, 2010
• Study Completion: December 1, 2011
• Last Updated: September 17, 2013

Record last verified: 2013-09