Trials Sponsors Conditions Drugs Pricing

Conditions

Genetic High Risk for Schizophrenia

Keywords

schizophreniastem cellsneuronsgenetic hish risk for schizophrenia

Outcome Measures

Primary Outcomes (1)

Structural and functional characteristics of neurons differentiated from adipose tissue derived stem cells in subjects with genetic high risk for schizophrenia and healthy controls
in vitro measurement of the expression of the neuronal markers for differentiated post-mitotic neuron, GABAergic/Glutamatergic neuron. The neuronal connectivity, neurites from soma and synaptic protein levels will be assessed. In addition, RNA and proteins expression (e.g. Glutamate/GABA receptors) , physiological function, and in vitro response to antipsychotics will be evaluated.
three years

Secondary Outcomes (7)

CAARMS(Comprehensive assessment of at risk mental states)
Baseline
PANSS(Positive and Negative Syndrome Scale)
Baseline
Neurocognitive function test battery (composite)
Baseline
ERP(event-related potential) profile
Baseline
Structural/resting functional MRI data
Baseline
+2 more secondary outcomes

Study Arms (2)

Genetic High Risk

Healthy Control

Eligibility Criteria

Age20 Years - 45 Years

Sexall

Healthy VolunteersYes

Age GroupsAdult (18-64)

Sampling MethodProbability Sample

Study Population

* Subjects at genetic high risk for schizophrenia * Healthy control

You may qualify if:

\[Subjects at genetic high risk for schizophrenia\]

Sponsors & Collaborators

Ministry of Health & Welfare, Korea
Governmentcollaborator
Seoul National University Hospital
Otherlead

Study Sites (1)

Seoul National University Hospital

Seoul, 110-744, South Korea

Biospecimen

Retention: SAMPLES WITH DNA

5-10mL of adipose cells in tumescent solution 5-10mL of venous blood

MeSH Terms

Conditions

Schizophrenia

Condition Hierarchy (Ancestors)

Schizophrenia Spectrum and Other Psychotic DisordersMental Disorders

Study Officials

Jun Soo Kwon, M.D., Ph.D.
Seoul National University Hospital
PRINCIPAL INVESTIGATOR

Enrollment

24 participants (actual enrollment reported by the registry).

Study Design

Study Type: observational
Observational Model: CASE CONTROL
Time Perspective: CROSS SECTIONAL
Sponsor Type: OTHER
Responsible Party: SPONSOR

Study Record Dates

First Submitted

September 4, 2013

First Posted

September 16, 2013

Study Start

September 2013

Actual (reported)

Stem Cell Research on Subjects at Genetic High Risk for Schizophrenia

Brief Summary

Registry Overview

Trial Relationships

Study Timeline

Study Start

First Submitted

First Posted

Primary Completion

Study Completion

Conditions

Keywords

Outcome Measures

Primary Outcomes (1)

Secondary Outcomes (7)

Study Arms (2)

Genetic High Risk

Healthy Control

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

Biospecimen

MeSH Terms

Conditions

Condition Hierarchy (Ancestors)

Study Officials

Enrollment

Study Design

Study Record Dates

You may not qualify if:

Source record

Locations

Brief Summary

Registry Overview

Trial Relationships

Related Scientific Literature

Study Timeline

Study Start

First Submitted

First Posted

Primary Completion

Study Completion

Conditions

Keywords

Outcome Measures

Primary Outcomes (1)

Secondary Outcomes (7)

Study Arms (2)

Genetic High Risk

Healthy Control

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

Biospecimen

MeSH Terms

Conditions

Condition Hierarchy (Ancestors)

Study Officials

Enrollment

Study Design

Study Record Dates

You may not qualify if:

Source record

Locations