NCT01942928

Brief Summary

Background Excessive Crying (Infantile Colic) is one of the most common complaints for which parents seek treatment. These otherwise healthy and well fed infants show no signs of failure to thrive, cry without identifiable cause, fuss a lot and are hard-to-soothe. Objective To explore the feasibility of running a Randomised Controlled Trial (RCT) that investigates the effectiveness of cranial osteopathy in addition to usual National Health Service (NHS) care in infants with colic. Methods Pragmatic randomised controlled trial, involving United Kingdom (UK) osteopaths in private practice and NHS health visitors. Parents of 60 excessively crying infants/infants with colic will be recruited by NHS health visitors. Infants will be included into the study if they are healthy (full-term) and aged 1-7 weeks, diagnosed with excessive crying/infantile colic, and have no co-morbidities. Participants will be randomised into the usual NHS care group or the usual NHS care plus cranial osteopathic intervention group. Usual NHS care will be provided by health visitors and osteopathic treatment will be carried out by experienced osteopaths in private practice. Primary outcome measures are acceptability and feasibility of intervention procedures. Furthermore, changes in the frequency and duration of crying will be documented in a daily crying diary. Parental quality of life will also be assessed. This pilot investigation will provide useful information in order to further develop and adapt the current interventions and trial procedures with a view to a full-scale randomised controlled trial.

Trial Health

55
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
60

participants targeted

Target at P25-P50 for not_applicable

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

September 11, 2013

Completed
5 days until next milestone

First Posted

Study publicly available on registry

September 16, 2013

Completed
9 months until next milestone

Study Start

First participant enrolled

June 1, 2014

Completed
2.5 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 1, 2016

Completed
Last Updated

February 20, 2015

Status Verified

February 1, 2015

Enrollment Period

2.5 years

First QC Date

September 11, 2013

Last Update Submit

February 19, 2015

Conditions

Outcome Measures

Primary Outcomes (1)

  • Change in daily hours crying time

    4 weeks

Secondary Outcomes (1)

  • Parental Quality of life

    4 weeks

Study Arms (2)

Usual NHS care

ACTIVE COMPARATOR
Other: Usual NHS Care

Usual NHS Care plus Osteopathic Manipulative Therapy

ACTIVE COMPARATOR
Other: Usual NHS CareOther: Osteopathic Manipulative Therapy

Interventions

Usual NHS care is provided by a health visitor who will diagnose excessively crying infants/infants with colic in the first instance. Parents usually will then have the opportunity to consult their health visitor when needed. The health visitor will provide support and advice on how to manage the condition within their professional remit.

Usual NHS Care plus Osteopathic Manipulative TherapyUsual NHS care

Osteopathic treatment will be provided by experienced osteopaths once a week for up to four weeks, depending on needs. Treatment will be individualised, according to clinical findings, and involves using standard cranial osteopathic techniques. All parents will be able to ask questions.

Usual NHS Care plus Osteopathic Manipulative Therapy

Eligibility Criteria

Age1 Week - 7 Weeks
Sexall
Healthy VolunteersNo
Age GroupsChild (0-17)

You may qualify if:

  • healthy, diagnosed with excessive crying by NHS Health Visitors No comorbidities Parents are able to adequately communicate in English

You may not qualify if:

  • Currently participating in other therapeutic clinical trials Currently receive manual therapy treatment

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

European School of Osteopathy

Maidstone, Kent, ME14 3DZ, United Kingdom

RECRUITING

MeSH Terms

Conditions

Colic

Interventions

Manipulation, Osteopathic

Condition Hierarchy (Ancestors)

Infant, Newborn, DiseasesCongenital, Hereditary, and Neonatal Diseases and Abnormalities

Intervention Hierarchy (Ancestors)

Musculoskeletal ManipulationsComplementary TherapiesTherapeuticsPhysical Therapy ModalitiesRehabilitation

Central Study Contacts

Anne Jakel, BSc (Hons) Ost, DPhil

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
INVESTIGATOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

September 11, 2013

First Posted

September 16, 2013

Study Start

June 1, 2014

Primary Completion

December 1, 2016

Last Updated

February 20, 2015

Record last verified: 2015-02

Locations