Study of Airway Inflammation in Relation to Exercise in Elite Athletes

NCT01942096 | Completed

• 1 other identifier: ML7650
• Study Type: observational
• Target: 66
• Locations: 1 country
• Sites: 1

Brief Summary

High school elite training programs are today more and more under development in several 'elite sport schools' in Belgium, in order to select and train future elite athletes already at young age. Little is known about the effects of sustained training on the potential development of asthma in adolescents during lung growth. It would be of great importance to be able to select the individuals at risk to develop exercise-induced asthma, already at the start of their enrollment in the 'elite sport school. This would allow physicians to follow their lung function parameters very closely and regularly; and, if necessary, start treatment early after the first signs of exercise-induced asthma.

Conditions

Exercise Induced Asthma

Outcome Measures

Primary Outcomes (1)

• Measurement of airway inflammation

  Airway inflammation upper and lower airways will be assessed by collection of nasal fluid (nasal sponge will be inserted in nostril for 5 minutes), Fraction of exhaled Nitric Oxide measurement and sputum induction.

  Baseline, immediately after and 24 hours after sport-specific training

Secondary Outcomes (1)

• Measurement of exercise induced bronchoconstriction

  baseline

Other Outcomes (3)

• Detection of allergy

  baseline

• Assessment of upper and lower airway symptoms

  Baseline, immediately after and 24 hours after sport-specific training

• Measurement of lung function and nasal patency

  at baseline, immediately after and 24 hours sport-specific training

Study Arms (3)

Competitive swimmers

Swimmers performing at national or international level

Competitive indoor athletes

Indoor athletes performing at national or international level

Healthy control individuals

Individuals performing sports at a recreational level

Eligibility Criteria

• Age: 14 Years - 25 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Competitive swimmers, competitive indoor athletes and healthy individuals

You may qualify if:

• Performing sports at national or international level (swimmers and indoor athletes)

You may not qualify if:

• Performing sport at recreational level (not more than 4 hours/week for healthy individuals)

Sponsors & Collaborators

• Universitaire Ziekenhuizen KU Leuven: lead

Study Sites (1)

UZ Leuven

Leuven, Vlaams-Brabant, 3000, Belgium

Location

Related Publications (2)

• Steelant B, Hox V, Van Gerven L, Dilissen E, Dekimpe E, Kasran A, Aertgeerts S, Van Belle V, Peers K, Dupont LJ, Hellings PW, Bullens DM, Seys SF. Nasal symptoms, epithelial injury and neurogenic inflammation in elite swimmers. Rhinology. 2018 Sep 1;56(3):279-287. doi: 10.4193/Rhin17.167.

  PMID: 29561921 RESULT

• Seys SF, Hox V, Van Gerven L, Dilissen E, Marijsse G, Peeters E, Dekimpe E, Kasran A, Aertgeerts S, Troosters T, Vanbelle V, Peers K, Ceuppens JL, Hellings PW, Dupont LJ, Bullens DM. Damage-associated molecular pattern and innate cytokine release in the airways of competitive swimmers. Allergy. 2015 Feb;70(2):187-94. doi: 10.1111/all.12540.

  PMID: 25358760 RESULT

Biospecimen

Retention: SAMPLES WITH DNA

induced sputum sample nasal fluid venous blood (serum)

MeSH Terms

Conditions

Asthma, Exercise-Induced

Condition Hierarchy (Ancestors)

Asthma; Bronchial Diseases; Respiratory Tract Diseases; Respiratory Hypersensitivity; Exercise-Induced Allergies; Hypersensitivity, Immediate; Hypersensitivity; Immune System Diseases

Study Officials

• Sven F Seys, MSc

  lab of clinical immunology, CDG 8th floor, Herestraat 49, 3000 Leuven

  STUDY DIRECTOR

• Valerie Hox, MD

  lab of clinical immunology, CDG 8th floor, Herestraat 49, 3000 Leuven

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: prof dr

Study Record Dates

• First Submitted: August 26, 2013
• First Posted: September 13, 2013
• Study Start: December 1, 2011
• Primary Completion: August 1, 2013
• Study Completion: August 1, 2013
• Last Updated: July 16, 2018

Record last verified: 2018-07

Data Sharing

• IPD Sharing: Will share

Locations

BE (1)