The Influence of Oxytocin on the Processing of Social Contact
2 other identifiers
interventional
40
1 country
1
Brief Summary
Social touch can convey the most potent and salient of socio-emotional signals. While the hypothalamic peptide oxytocin (OXT) has been identified as a key neurochemical mediator of grooming in some other social species, its modulatory influence on human interpersonal touch is unknown. The investigators expect that OXT augments the hedonic value of touch and that this behavioral effect is paralleled at the neural level by an increased response in brain areas mediating rewarding aspects of social touch.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for phase_1
Started Mar 2013
Shorter than P25 for phase_1
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
March 1, 2013
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 1, 2013
CompletedStudy Completion
Last participant's last visit for all outcomes
August 1, 2013
CompletedFirst Submitted
Initial submission to the registry
August 27, 2013
CompletedFirst Posted
Study publicly available on registry
September 11, 2013
CompletedSeptember 11, 2013
September 1, 2013
3 months
August 27, 2013
September 5, 2013
Conditions
Keywords
Outcome Measures
Primary Outcomes (2)
Pleasantness ratings of social touch
After each trial, subjects are asked to use a visual analog scale to rate the pleasantness of the administered touch.
30 minutes after the nasal spray administration
Blood-oxygen-level dependent signal in response to social touch
By using functional magnetic resonance imaging we want to examine oxytocin's effects on the neural correlates (BOLD signal) of social touch.
30 minutes after the nasal spray administration
Secondary Outcomes (1)
Questionnaire measurement of mood (PANAS) and anxiety (STAI).
15 minutes before the nasal spray administration and (on average) 10 minutes after the fMRI experiment
Other Outcomes (1)
Saliva oxytocin concentrations
15 minutes before the nasal spray administration and (on average) 10 minutes after the fMRI experiment
Study Arms (2)
Oxytocin
EXPERIMENTAL24 IU Oxytocin, intranasal application 30 min prior to the experiment
Placebo
PLACEBO COMPARATORintranasal application, sodium chloride solution, 3 puffs per nostril
Interventions
Eligibility Criteria
You may qualify if:
- Healthy male volunteers
You may not qualify if:
- Current or past psychiatric disease Current or past physical illness Psychoactive medication Tobacco smokers
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Department of Psychiatry, University of Bonn
Bonn, North Rhine-Westphalia, 53105, Germany
Related Links
MeSH Terms
Interventions
Intervention Hierarchy (Ancestors)
Study Design
- Study Type
- interventional
- Phase
- phase 1
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- PARTICIPANT, INVESTIGATOR
- Purpose
- BASIC SCIENCE
- Intervention Model
- CROSSOVER
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- MD PhD M.Sc.
Study Record Dates
First Submitted
August 27, 2013
First Posted
September 11, 2013
Study Start
March 1, 2013
Primary Completion
June 1, 2013
Study Completion
August 1, 2013
Last Updated
September 11, 2013
Record last verified: 2013-09