Colloid Improves Organs Function in Resuscitation of Extensive Burn Patients
Colloid Improves Organ Function by Reducing the Elevation of Intra-abdominal Pressure in Resuscitation of Critical Burn Patients
1 other identifier
observational
47
1 country
1
Brief Summary
The present study was to evaluate the effectiveness of colloid compared with crystalloids for fluid resuscitation in critical burn patients with total burn surface area ≥50%.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for all trials
Started Jul 2010
Typical duration for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
July 1, 2010
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 1, 2013
CompletedStudy Completion
Last participant's last visit for all outcomes
July 1, 2013
CompletedFirst Submitted
Initial submission to the registry
August 30, 2013
CompletedFirst Posted
Study publicly available on registry
September 11, 2013
CompletedSeptember 11, 2013
September 1, 2013
2.9 years
August 30, 2013
September 5, 2013
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Multiple organs function score (MODS) of extensive burns
48 hours during fluid resuscitation
Secondary Outcomes (1)
Intra-abdominal pressure (IAP) of extensive burns
48 hours during fluid resuscitation
Study Arms (2)
Parkland group
Extensive burn patients are resuscitated with Parkland formula.In the first 24h of resuscitation,crystalloids were infused as the main fluid.
TMMU group
Extensive burn patients are resuscitated with Third Military Medical University (TMMU) formula as a modified EVANS formula routinely used in China. In the first 24h of resuscitation, crystalloids and colloids were infused together.
Interventions
TMMU group allows for administration of colloids early,while Parkland group infuse colloids 24 h after burn injury.
Eligibility Criteria
This study was performed in the Department of Burn Intensive Care of the Tangdu Hospital, an academic hospital of the Fourth Military Medical University of Xi'an. populaitons were extensive burns who admitted to our hospital within 4 h since burn injury.
You may qualify if:
- burn patients with total burn surface area ≥50% and full thickness burn surface area ≥30%.
You may not qualify if:
- age \<18 yrs, time between burn injury and fluid infusion \> 4 h, time arriving at our burn centre \> 6 h, pre-existing medical illnesses compromising the cardiopulmonary reserve or those need for compassionate care only.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Tang-Du Hospitallead
Study Sites (1)
Department of Burn and Plastic Surgery,Tangdu Hospital
Xi'an, Shaanxi, 710038, China
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- STUDY DIRECTOR
Xueyong Li, MD
Department of Burn and Plastic Sugery
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- PROSPECTIVE
- Target Duration
- 2 Days
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Mr Honghui Zhang
Study Record Dates
First Submitted
August 30, 2013
First Posted
September 11, 2013
Study Start
July 1, 2010
Primary Completion
June 1, 2013
Study Completion
July 1, 2013
Last Updated
September 11, 2013
Record last verified: 2013-09