Hemodynamic Changes of Patients Receiving Atenolol/Bisoprolol
CHAB
Comparison of the Hemodynamic Changes in Patients Under Treatment With Bisoprolol Versus Atenolol
1 other identifier
interventional
80
1 country
3
Brief Summary
At hemodynamic level, the greater affinity of bisoprolol by the beta 1 receptor in theory could improve the peripheral arterial perfusion and could have a greater antihypertensive effect. At the same time, this could carry objectifiable improvements in the vascular tree, such as the level of arterial stiffness. This study attempts to mark the hemodynamic differences in the same individual with hypertension and metabolic syndrome who will be exposed to both drugs at different moments. Parameters will be objectified with impedance cardiography, pulse wave velocity and central blood pressure assessment before and after taking each one of the drugs. The results will be compared to the baseline data and between themselves.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for phase_4 hypertension
Started Feb 2012
Typical duration for phase_4 hypertension
3 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
February 1, 2012
CompletedStudy Start
First participant enrolled
February 1, 2012
CompletedFirst Posted
Study publicly available on registry
September 11, 2013
CompletedPrimary Completion
Last participant's last visit for primary outcome
October 1, 2014
CompletedStudy Completion
Last participant's last visit for all outcomes
November 1, 2014
CompletedDecember 5, 2014
December 1, 2014
2.7 years
February 1, 2012
December 4, 2014
Conditions
Outcome Measures
Primary Outcomes (1)
central blood pressure
two months
Secondary Outcomes (3)
peripheral resistance
two months
cardiac index
two months
pulse wave velocity
two months
Study Arms (1)
Atenolol-Bisoprolol
EXPERIMENTALInterventions
Eligibility Criteria
You may qualify if:
- Hypertension
- Metabolic syndrome
You may not qualify if:
- Severe hypertension \>180/110
- Secondary hypertension
- Contraindication for betablockers
- History of neoplastic disease
- Patients that do not sign informed consent
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (3)
Hospital Italiano de Buenos Aires
Buenos Aires, C1181ACH, Argentina
Hospital Italiano de Buenos Aires
Buenos Aires, c118ach, Argentina
Hospital Italiano de Buenos Aires
Buenos Aires, Argentina
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- STUDY DIRECTOR
Gabriel D Waisman, MD
Hospital Italiano de Buenos Aires
Study Design
- Study Type
- interventional
- Phase
- phase 4
- Allocation
- NA
- Masking
- NONE
- Purpose
- HEALTH SERVICES RESEARCH
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- MD
Study Record Dates
First Submitted
February 1, 2012
First Posted
September 11, 2013
Study Start
February 1, 2012
Primary Completion
October 1, 2014
Study Completion
November 1, 2014
Last Updated
December 5, 2014
Record last verified: 2014-12