Randomized Comparison of Continuous and Intermittent Heparin Infusion During Catheter Ablation of Atrial Fibrillation
COHERE
1 other identifier
interventional
296
1 country
1
Brief Summary
Optimal anticoagulation using heparin with close attention to maintain therapeutic dosing during the procedure is important. Randomized comparison of continuous and intermittent heparin infusion during catheter ablation of Atrial Fibrillation.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for phase_3
Started Dec 2012
Typical duration for phase_3
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
December 1, 2012
CompletedFirst Submitted
Initial submission to the registry
September 1, 2013
CompletedFirst Posted
Study publicly available on registry
September 5, 2013
CompletedPrimary Completion
Last participant's last visit for primary outcome
July 1, 2015
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2015
CompletedApril 14, 2016
April 1, 2016
2.6 years
September 1, 2013
April 13, 2016
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
therapeutic ACT retention rate during procedure
2 years
Study Arms (2)
Continuous heparin infusion group
ACTIVE COMPARATORcontinuous group is given an initial intravenous heparin 100u/kg and then maintain heparin infusion during procedural.
Intermittent heparin infusion group
ACTIVE COMPARATORIntermittent group is given an initial intravenous heparin 100u/kg. Then The ACT is tested every 30min with administration of additional heparin boluses and titration of the heparin drip based on the results and according to the judgment of the operating physician.
Interventions
continuous group is given an initial intravenous heparin 100u/kg and then maintain heparin infusion during procedural.
Intermittent group is given an initial intravenous heparin 100u/kg. Then The ACT is tested every 30min with administration of additional heparin boluses and titration of the heparin drip based on the results and according to the judgment of the operating physician.
Eligibility Criteria
You may qualify if:
- Atrial Fibrillation, Radiofrequency catheter ablation scheduled
You may not qualify if:
- Clinical trial denied
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Yong Seog Ohlead
Study Sites (1)
Seoul st. mary's hospital
Seoul, South Korea
Related Publications (1)
Kim TS, Kim SH, Kim BK, Kim JY, Kim JH, Jang SW, Lee MY, Rho TH, Oh YS. Randomized Comparison of Continuous Versus Intermittent Heparin Infusion During Catheter Ablation of Atrial Fibrillation. JACC Clin Electrophysiol. 2016 Jun;2(3):319-326. doi: 10.1016/j.jacep.2015.11.004. Epub 2015 Dec 9.
PMID: 29766891DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Yong Seog Oh, MD
Seoul St. Mary's Hospital
Study Design
- Study Type
- interventional
- Phase
- phase 3
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- PARTICIPANT
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR INVESTIGATOR
- PI Title
- Professor
Study Record Dates
First Submitted
September 1, 2013
First Posted
September 5, 2013
Study Start
December 1, 2012
Primary Completion
July 1, 2015
Study Completion
December 1, 2015
Last Updated
April 14, 2016
Record last verified: 2016-04