Study on the Interplay Between Twist1 and Other EMT Regulators Through microRNA-29 Family.

NCT01927354 | Unknown DMC

• 1 other identifier: 201112085RID
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

Investigation of the molecular mechanism and clinical significance of the interplay between Twist1 and other EMT regulators through microRNA-29 family.

Conditions

Head-and-Neck Squamous Cell Carcinoma

Keywords

Head-and-Neck squamous cell carcinoma (HNSCC); epithelial-mesenchymal transition (EMT); microRNA29; Twist1

Outcome Measures

Primary Outcomes (1)

• The interplay between Twist1 and other EMT regulators throigh microRNA-29 family

  3 years

Study Arms (1)

Head and neck cancer

Subjects who suffer from oral cancer. Collect a 0.5x0.5Cm2 tissue sample of the tumor during the surgery.

Eligibility Criteria

• Age: 20 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Medical center

You may qualify if:

• Head and neck cancer

You may not qualify if:

• pregnant woman

Sponsors & Collaborators

• National Taiwan University Hospital: lead

Study Sites (1)

National Taiwan University Hospital research Ethics Committee

Taipei, 10048, Taiwan

RECRUITING

Related Publications (51)

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• Yang MH, Hsu DS, Wang HW, Wang HJ, Lan HY, Yang WH, Huang CH, Kao SY, Tzeng CH, Tai SK, Chang SY, Lee OK, Wu KJ. Bmi1 is essential in Twist1-induced epithelial-mesenchymal transition. Nat Cell Biol. 2010 Oct;12(10):982-92. doi: 10.1038/ncb2099. Epub 2010 Sep 5.

  PMID: 20818389 RESULT

• Yang MH, Wu KJ. TWIST activation by hypoxia inducible factor-1 (HIF-1): implications in metastasis and development. Cell Cycle. 2008 Jul 15;7(14):2090-6. doi: 10.4161/cc.7.14.6324. Epub 2008 May 21.

  PMID: 18635960 RESULT

• Yang MH, Wu MZ, Chiou SH, Chen PM, Chang SY, Liu CJ, Teng SC, Wu KJ. Direct regulation of TWIST by HIF-1alpha promotes metastasis. Nat Cell Biol. 2008 Mar;10(3):295-305. doi: 10.1038/ncb1691. Epub 2008 Feb 24.

  PMID: 18297062 RESULT

Biospecimen

Retention: SAMPLES WITH DNA

tissue

MeSH Terms

Conditions

Squamous Cell Carcinoma of Head and Neck; Acrocephalosyndactylia

Condition Hierarchy (Ancestors)

Carcinoma, Squamous Cell; Carcinoma; Neoplasms, Glandular and Epithelial; Neoplasms by Histologic Type; Neoplasms; Head and Neck Neoplasms; Neoplasms by Site; Craniosynostoses; Synostosis; Dysostoses; Bone Diseases, Developmental; Bone Diseases; Musculoskeletal Diseases; Syndactyly; Craniofacial Abnormalities; Musculoskeletal Abnormalities; Limb Deformities, Congenital; Congenital Abnormalities; Congenital, Hereditary, and Neonatal Diseases and Abnormalities

Study Officials

• Shin-Jung Cheng, DDS, MS, PhD

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Shin-Jung Cheng, DDS, MS, PhD

CONTACT

+886 2 29251733; sjcheng56@ntu.edu.tw

Study Design

• Study Type: observational
• Observational Model: COHORT
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 7, 2013
• First Posted: August 22, 2013
• Study Start: December 1, 2012
• Primary Completion: March 1, 2014
• Study Completion: March 1, 2014
• Last Updated: September 16, 2013

Record last verified: 2013-09

Locations

TW (1)