NCT01926249|Completed
A Cohort of Outpatients From French Research Memory Centers in Order to Improve Knowledge on Alzheimer's Disease and Related Disorders
MEMENTO
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MEMENTO
Sponsor study identifier
observational
2,325
1 country
29
Study Start
December 8, 2011
Actual (reported)Primary Completion
October 29, 2021
Actual (reported)Study Completion
October 29, 2021
Actual (reported)A Multicenter national prospective cohort study including at least 2300 individuals consecutively recruited from French Research Memory Centers and followed-up over 5 years.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
October 29, 2021
Actual (reported)Click on a node to explore related trials.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
December 8, 2011
Actual (reported)August 16, 2013
Actual (reported)August 20, 2013
Actual (reported)October 29, 2021
Actual (reported)October 29, 2021
Actual (reported)Progression to clinical dementia stage according to standardized classifications (DSM-IV for dementia and NINCDS-ADRDA for Alzheimer's disease)
Each 6 months from baseline for 5 years (M60)
Mortality
Each 6 months from baseline for 5 years (M60)
Loss of autonomy based on functional activity assessment
Each 6 months from baseline for 5 years (M60)
Institutionalisation
Each 6 months from baseline for 5 years (M60)
Speed of cognitive decline based on change in cognitive performances
Each 6 months from baseline for 5 years (M60)
Cardiovascular event (Stroke and Coronary events)
Each 6 months from baseline for 5 years (M60)
* 2000 participants with a newly identified cognitive deficit defined as performing worse than one standard deviation to the mean in one or more cognitive domain (memory, language, praxis, visuospatial abilities, attention and executive functions), not demented. * 300 participants with an isolated cognitive complaint and an age of 60 years or more.
Outpatients from French Research Memory Centers with at least a light cognitive deficit defined as performing worse than one standard deviation to the mean in one or more cognitive domains or an isolated cognitive complaint regardless of its duration while being 60 years and older.
CHU d'Amiens
Amiens, France
CHU d'Angers
Angers, France
CHU de Besançon
Besançon, France
AP-HP - Avicenne
Bobigny, France
CHU de Bordeaux - Pellegrin
Bordeaux, 33000, France
CHU de Bordeaux - Hôpital Xavier-Arnozan
Bordeaux, France
CHU de Brest
Brest, France
CHU de Clermont-Ferrand
Blanc F, Bouteloup V, Paquet C, Chupin M, Pasquier F, Gabelle A, Ceccaldi M, de Sousa PL, Krolak-Salmon P, David R, Fischer C, Dartigues JF, Wallon D, Moreaud O, Sauvee M, Belin C, Roubaud C, Botzung A, Ravier A, Demuynck C, Namer I, Habert MO, Bousiges O, Schorr B, Muller C, Philippi N, Chene G, Cretin B, Mangin JF, Dufouil C. Cognitive and neuroimaging outcome of very prodromal dementia with Lewy bodies. Geroscience. 2026 Feb;48(1):1051-1062. doi: 10.1007/s11357-025-01701-x. Epub 2025 May 25.
Lespinasse J, Dufouil C, Proust-Lima C. Disease progression model anchored around clinical diagnosis in longitudinal cohorts: example of Alzheimer's disease and related dementia. BMC Med Res Methodol. 2023 Sep 5;23(1):199. doi: 10.1186/s12874-023-02009-0.
* Blood sampling * Lumbar puncture (samples without DNA)
Genevieve CHENE, Prof
CIC-EC7 - ISPED - CHU de Bodeaux
Geneviève CHENE, Prof
CIC-EC7 - ISPED - CHU de Bordeaux
Carole DUFOUIL, Director
CIC-EC7 - ISPED - CHU de Bordeaux
2,325 participants (actual enrollment reported by the registry).
First Submitted
August 16, 2013
First Posted
August 20, 2013
Study Start
December 8, 2011
Actual (reported)Contact the study team to confirm eligibility.
Clermont-Ferrand, France
Hôpitaux civils de Colmar
Colmar, France
CHU de Dijon
Dijon, France
CHU de Grenoble
Grenoble, France
CHU de Lille
Lille, France
Hospices civils de Lyon
Lyon, France
AP-HM
Marseille, France
CHU de Montpellier
Montpellier, France
CHU de Nancy
Nancy, France
CHU de Nantes
Nantes, France
CHU de Nice
Nice, France
AP-HP - Hôpital BROCA
Paris, France
AP-HP - Hôpital LARIBOISIERE
Paris, France
Ap-Hp La Pitié-Salpêtrière
Paris, France
CHU de Poitiers
Poitiers, France
CHU de Rouen
Rouen, France
CHU de Saint-Etienne - Hôpital de la charité
Saint-Etienne, France
CHU de Saint-Etienne - Hôpital Nord
Saint-Etienne, France
CHU de Strasbourg
Strasbourg, France
CHU de Toulouse - Hôpital Purpan
Toulouse, France
CHU de Toulouse
Toulouse, France
CHU de Tours
Tours, France
Blanc F, Bouteloup V, Paquet C, Chupin M, Pasquier F, Gabelle A, Ceccaldi M, de Sousa PL, Krolak-Salmon P, David R, Fischer C, Dartigues JF, Wallon D, Moreaud O, Sauvee M, Belin C, Harston S, Botzung A, Albasser T, Demuynck C, Namer I, Habert MO, Kremer S, Bousiges O, Verny M, Muller C, Philippi N, Chene G, Cretin B, Mangin JF, Dufouil C. Prodromal characteristics of dementia with Lewy bodies: baseline results of the MEMENTO memory clinics nationwide cohort. Alzheimers Res Ther. 2022 Jul 19;14(1):96. doi: 10.1186/s13195-022-01037-0.
Dufouil C, Dubois B, Vellas B, Pasquier F, Blanc F, Hugon J, Hanon O, Dartigues JF, Harston S, Gabelle A, Ceccaldi M, Beauchet O, Krolak-Salmon P, David R, Rouaud O, Godefroy O, Belin C, Rouch I, Auguste N, Wallon D, Benetos A, Pariente J, Paccalin M, Moreaud O, Hommet C, Sellal F, Boutoleau-Bretonniere C, Jalenques I, Gentric A, Vandel P, Azouani C, Fillon L, Fischer C, Savarieau H, Operto G, Bertin H, Chupin M, Bouteloup V, Habert MO, Mangin JF, Chene G; MEMENTO cohort Study Group. Cognitive and imaging markers in non-demented subjects attending a memory clinic: study design and baseline findings of the MEMENTO cohort. Alzheimers Res Ther. 2017 Aug 29;9(1):67. doi: 10.1186/s13195-017-0288-0.
Primary Completion
October 29, 2021
Actual (reported)Study Completion
October 29, 2021
Actual (reported)Last Updated
January 11, 2022
Record last verified: 2022-01
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