NCT01924507

Brief Summary

The investigators aimed to evaluated the role of bedside sleep medicine in an cardiology intensive care unit. The patients will be submitted to a overnight polysomnography. Those individuals with sleep apnea will be treated with CPAP during the ICU admission. Also, the investigators will identify the factors that compromise the sleep and will act to minimize them to improve the sleep quality. After the interventions, the investigators will evaluate if there are reduced days of hospital admission, major cardiovascular events (infarction, reinfarction, heart failure and stroke) and overall mortality.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
400

participants targeted

Target at P75+ for not_applicable

Timeline
Completed

Started Aug 2013

Typical duration for not_applicable

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

August 1, 2013

Completed
Same day until next milestone

Primary Completion

Last participant's last visit for primary outcome

August 1, 2013

Completed
13 days until next milestone

First Submitted

Initial submission to the registry

August 14, 2013

Completed
2 days until next milestone

First Posted

Study publicly available on registry

August 16, 2013

Completed
2.3 years until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2015

Completed
Last Updated

August 16, 2013

Status Verified

August 1, 2013

Enrollment Period

Same day

First QC Date

August 14, 2013

Last Update Submit

August 15, 2013

Conditions

Keywords

Sleep medicineSleep apneaAcute myocardial infarctionHeart failureCPAP

Outcome Measures

Primary Outcomes (1)

  • days of admission

    Days of admission in the cardiology intensive care unit

    7 days

Secondary Outcomes (1)

  • Combination of acute myocardial infarction, reinfarction, heart failure and stroke

    12 months

Other Outcomes (1)

  • Overall mortality

    12 months

Study Arms (2)

CPAP

EXPERIMENTAL

Patients with apnea will be treated with CPAP during the night.

Device: CPAP

Control

NO INTERVENTION

One arm group will be control and will not receive CPAP treatment during the ICU admission.

Interventions

CPAPDEVICE

CPAP - continuous positive air pressure in patients with sleep apnea

CPAP

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Acute myocardial infarction
  • Acute decompensated heart failure
  • Age \> 18 years-old
  • Cardiology intensive care unit admission

You may not qualify if:

  • Intravenous sedation
  • Invasive mechanical ventilation
  • hemodynamic instability
  • use of intravenous vasoactive drugs
  • acute respiratory failure

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Hospital Sao Paulo - Federal University of Sao Paulo

São Paulo, São Paulo, 04128000, Brazil

RECRUITING

Related Publications (7)

  • Freedman NS, Kotzer N, Schwab RJ. Patient perception of sleep quality and etiology of sleep disruption in the intensive care unit. Am J Respir Crit Care Med. 1999 Apr;159(4 Pt 1):1155-62. doi: 10.1164/ajrccm.159.4.9806141.

    PMID: 10194160BACKGROUND
  • Richards KC, O'Sullivan PS, Phillips RL. Measurement of sleep in critically ill patients. J Nurs Meas. 2000 Fall-Winter;8(2):131-44.

    PMID: 11227580BACKGROUND
  • Aaron JN, Carlisle CC, Carskadon MA, Meyer TJ, Hill NS, Millman RP. Environmental noise as a cause of sleep disruption in an intermediate respiratory care unit. Sleep. 1996 Nov;19(9):707-10. doi: 10.1093/sleep/19.9.707.

    PMID: 9122557BACKGROUND
  • Gami AS, Olson EJ, Shen WK, Wright RS, Ballman KV, Hodge DO, Herges RM, Howard DE, Somers VK. Obstructive sleep apnea and the risk of sudden cardiac death: a longitudinal study of 10,701 adults. J Am Coll Cardiol. 2013 Aug 13;62(7):610-6. doi: 10.1016/j.jacc.2013.04.080. Epub 2013 Jun 13.

    PMID: 23770166BACKGROUND
  • Martinez-Garcia MA, Campos-Rodriguez F, Catalan-Serra P, Soler-Cataluna JJ, Almeida-Gonzalez C, De la Cruz Moron I, Duran-Cantolla J, Montserrat JM. Cardiovascular mortality in obstructive sleep apnea in the elderly: role of long-term continuous positive airway pressure treatment: a prospective observational study. Am J Respir Crit Care Med. 2012 Nov 1;186(9):909-16. doi: 10.1164/rccm.201203-0448OC. Epub 2012 Sep 13.

    PMID: 22983957BACKGROUND
  • Elliott R, McKinley S, Cistulli P. The quality and duration of sleep in the intensive care setting: an integrative review. Int J Nurs Stud. 2011 Mar;48(3):384-400. doi: 10.1016/j.ijnurstu.2010.11.006. Epub 2010 Dec 24.

    PMID: 21185560BACKGROUND
  • Marin JM, Carrizo SJ, Vicente E, Agusti AG. Long-term cardiovascular outcomes in men with obstructive sleep apnoea-hypopnoea with or without treatment with continuous positive airway pressure: an observational study. Lancet. 2005 Mar 19-25;365(9464):1046-53. doi: 10.1016/S0140-6736(05)71141-7.

    PMID: 15781100BACKGROUND

MeSH Terms

Conditions

Sleep Wake DisordersSleep Apnea SyndromesHeart Failure

Condition Hierarchy (Ancestors)

Nervous System DiseasesNeurologic ManifestationsSigns and SymptomsPathological Conditions, Signs and SymptomsMental DisordersApneaRespiration DisordersRespiratory Tract DiseasesSleep Disorders, IntrinsicDyssomniasHeart DiseasesCardiovascular Diseases

Central Study Contacts

Fatima Cintra, MD, PhD

CONTACT

Luciana Storti Mancuso, BSN

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
MD, PhD

Study Record Dates

First Submitted

August 14, 2013

First Posted

August 16, 2013

Study Start

August 1, 2013

Primary Completion

August 1, 2013

Study Completion

December 1, 2015

Last Updated

August 16, 2013

Record last verified: 2013-08

Locations