Smoking Ban and Paediatric Hospital Admissions for Respiratory Tract Infections in England

NCT01920165 | Completed

• 1 other identifier: TRF NR-0166-1
• Study Type: observational
• Target: 1,660,652
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to investigate whether there has been a change in the number of hospital admissions for respiratory tract infections among children following the July 2007 introduction of a ban on smoking in public places in England.

Conditions

Respiratory Tract Infections; Upper Respiratory Tract Infections; Lower Respiratory Tract Infections

Keywords

respiratory tract infections; upper respiratory tract infections; lower respiratory tract infections; hospitalisation; child; children; minors; infants; second-hand smoke; tobacco smoke pollution; smoke-free; smoke-free policy; smoke-free legislation; public places

Outcome Measures

Primary Outcomes (1)

• rate of unplanned hospital admissions for acute RTIs

  The primary outcome is the rate of unplanned hospital admissions for acute RTIs. The following International Classification of Diseases (ICD)-10 codes will be used to identify acute RTIs: URTIs: A37, H66-H67, J02.0, J00-J06, J09-J11 (excluding J10.0, J11.0) LRTIs: J10.0, J11.0, J12-J18, J20-J22, J40-J42 Only unplanned hospitalisations where either a primary or first secondary diagnosis of an acute RTI is recorded, will be included. Admissions with a primary diagnosis of asthma are excluded to prevent overlap with a previous study assessing the impact of the English smoking ban on paediatric asthma hospitalisations. Transfers between hospitals following initial admission will not be included. As a unique patient identifier is not available in the source database, it is not possible to distinguish between first and subsequent admissions for individual children.

  up to 12 years

Secondary Outcomes (2)

• rate of unplanned hospital admissions for acute upper RTIs

  up to 12 years

• rate of unplanned hospital admissions for acute lower RTIs

  up to 12 years

Study Arms (1)

Full cohort

The population at risk for each time point is the number of children living in England aged 0-14 year

Other: Smoke-free legislation

Interventions

Smoke-free legislation OTHER

The intervention under study is the smoke-free legislation in England introduced overnight on 1 July 2007. As of this date virtually all enclosed public places and workplaces are by law required to be smoke-free. More detail can be found at: http://www.smokefreeengland.co.uk

Full cohort

Eligibility Criteria

• Age: Up to 14 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17)
• Sampling Method: Probability Sample

Study Population

The population at risk for each time point is the number of children living in England aged 0-14 years

You may qualify if:

• age 0-14 years
• living in England

You may not qualify if:

• hospital admissions with primary diagnosis of asthma
• transfers between hospitals

Sponsors & Collaborators

• University of Edinburgh: lead
• Imperial College London: collaborator
• Maastricht University: collaborator

Study Sites (1)

University of Edinburgh

Edinburgh, Midlothian, EH8 9AG, United Kingdom

Location

Related Publications (5)

• Jones LL, Hashim A, McKeever T, Cook DG, Britton J, Leonardi-Bee J. Parental and household smoking and the increased risk of bronchitis, bronchiolitis and other lower respiratory infections in infancy: systematic review and meta-analysis. Respir Res. 2011 Jan 10;12(1):5. doi: 10.1186/1465-9921-12-5.

  PMID: 21219618 BACKGROUND

• Jones LL, Hassanien A, Cook DG, Britton J, Leonardi-Bee J. Parental smoking and the risk of middle ear disease in children: a systematic review and meta-analysis. Arch Pediatr Adolesc Med. 2012 Jan;166(1):18-27. doi: 10.1001/archpediatrics.2011.158. Epub 2011 Sep 5.

  PMID: 21893640 BACKGROUND

• Millett C, Lee JT, Laverty AA, Glantz SA, Majeed A. Hospital admissions for childhood asthma after smoke-free legislation in England. Pediatrics. 2013 Feb;131(2):e495-501. doi: 10.1542/peds.2012-2592. Epub 2013 Jan 21.

  PMID: 23339216 BACKGROUND

• Oberg M, Jaakkola MS, Woodward A, Peruga A, Pruss-Ustun A. Worldwide burden of disease from exposure to second-hand smoke: a retrospective analysis of data from 192 countries. Lancet. 2011 Jan 8;377(9760):139-46. doi: 10.1016/S0140-6736(10)61388-8.

  PMID: 21112082 BACKGROUND

• Been JV, Millett C, Lee JT, van Schayck CP, Sheikh A. Smoke-free legislation and childhood hospitalisations for respiratory tract infections. Eur Respir J. 2015 Sep;46(3):697-706. doi: 10.1183/09031936.00014615. Epub 2015 May 28.

  PMID: 26022951 DERIVED

Related Links

• Detailed description of intervention under study

MeSH Terms

Conditions

Respiratory Tract Infections

Condition Hierarchy (Ancestors)

Infections; Respiratory Tract Diseases

Study Officials

• Jasper V Been, MD MPH PhD

  University of Edinburgh

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: ECOLOGIC OR COMMUNITY
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Dr.

Study Record Dates

• First Submitted: August 5, 2013
• First Posted: August 9, 2013
• Study Start: January 1, 2001
• Primary Completion: December 1, 2012
• Study Completion: December 1, 2012
• Last Updated: August 13, 2013

Record last verified: 2013-08

Locations

GB (1)