Lifestyle in Pregnancy and Offspring
LiPO
The Effect of Lifestyle Intervention in Pregnancy - Follow-up on the Offspring in Early Childhood.
1 other identifier
interventional
157
1 country
1
Brief Summary
Children born to obese women are at risk of increased adiposity and later adverse metabolic outcomes. We have conducted a follow-up study on an existing clinical trial, called the LiP study (Lifestyle in Pregnancy), registration number NCT00530439,in which 360 obese pregnant women were randomized to either lifestyle intervention or routine obstetric care. This present study follows the children until 3 years of age. We have the hypothesis, that the intervention during pregnancy results in a lower degree of adiposity and metabolic risk factors in the offspring. Clinical examination is taking place at age 2.5-3 years including anthropometric measurements, Dual energy x-ray (DXA) scans and blood samples measuring metabolic markers.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable
Started Feb 2011
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
February 1, 2011
CompletedPrimary Completion
Last participant's last visit for primary outcome
November 1, 2012
CompletedStudy Completion
Last participant's last visit for all outcomes
November 1, 2012
CompletedFirst Submitted
Initial submission to the registry
August 2, 2013
CompletedFirst Posted
Study publicly available on registry
August 7, 2013
CompletedSeptember 3, 2019
August 1, 2019
1.8 years
August 2, 2013
August 30, 2019
Conditions
Outcome Measures
Primary Outcomes (1)
Body Mass Index standard deviation score
On average 2.9 years of age
Secondary Outcomes (1)
Fat mass percent
On average 2.9 years of age
Other Outcomes (1)
Anthropometric and metabolic risk factors and bone mineralization
On average 2.9 years of age
Study Arms (2)
Lifestyle intervention
EXPERIMENTALThe active intervention consisted of two major components: dietary counseling and physical activity. Dietary counseling was performed by trained dieticians on four separate occasions at 15, 20, 28 and 35 weeks gestation.
Control
NO INTERVENTIONInterventions
Energy requirements for each participant were individually estimated according to weight and level of activity during pregnancy. Women in the active intervention group were encouraged to be moderately physically active 30-60 minutes a day.Women in this group also had free full time membership in a fitness center for six months. In the fitness centers they had closed training classes with trained physiotherapists for one hour each week.
Eligibility Criteria
You may qualify if:
- singleton pregnant
- BMI \>/= 30 and \</= 45 E xclusion Criteria for preceding LiP study:
- Chronic diseases
- Not Danish speaking
- Abuse of alcohol or drugs
- Preterm delivery in earlier pregnancies
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Department of Endocrinology, Odense University Hospital
Odense, 5000, Denmark
Related Publications (4)
Vinter CA, Jensen DM, Ovesen P, Beck-Nielsen H, Jorgensen JS. The LiP (Lifestyle in Pregnancy) study: a randomized controlled trial of lifestyle intervention in 360 obese pregnant women. Diabetes Care. 2011 Dec;34(12):2502-7. doi: 10.2337/dc11-1150. Epub 2011 Oct 4.
PMID: 21972411BACKGROUNDLuef BM, Stentebjerg LL, Tanvig MH, Aalders J, Moller S, Ovesen PG, Christesen HT, McIntyre HD, Catalano PM, Jorgensen JS, Overgaard M, Jensen DM, Vinter CA. Impact of maternal fasting blood glucose in pregnancy on body composition, anthropometric, and metabolic outcomes in newborns and 3-Year-Old offspring: results from the lifestyle in pregnancy and offspring study. BMC Pregnancy Childbirth. 2026 Jan 29. doi: 10.1186/s12884-026-08692-3. Online ahead of print.
PMID: 41612293DERIVEDTanvig M, Vinter CA, Jorgensen JS, Wehberg S, Ovesen PG, Beck-Nielsen H, Christesen HT, Jensen DM. Effects of lifestyle intervention in pregnancy and anthropometrics at birth on offspring metabolic profile at 2.8 years: results from the Lifestyle in Pregnancy and Offspring (LiPO) study. J Clin Endocrinol Metab. 2015 Jan;100(1):175-83. doi: 10.1210/jc.2014-2675.
PMID: 25343235DERIVEDTanvig M, Vinter CA, Jorgensen JS, Wehberg S, Ovesen PG, Lamont RF, Beck-Nielsen H, Christesen HT, Jensen DM. Anthropometrics and body composition by dual energy X-ray in children of obese women: a follow-up of a randomized controlled trial (the Lifestyle in Pregnancy and Offspring [LiPO] study). PLoS One. 2014 Feb 24;9(2):e89590. doi: 10.1371/journal.pone.0089590. eCollection 2014.
PMID: 24586896DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Mette Tanvig, MD
Department of endocrinology, Odense University Hospital
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- OUTCOMES ASSESSOR
- Purpose
- PREVENTION
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Medical Doctor
Study Record Dates
First Submitted
August 2, 2013
First Posted
August 7, 2013
Study Start
February 1, 2011
Primary Completion
November 1, 2012
Study Completion
November 1, 2012
Last Updated
September 3, 2019
Record last verified: 2019-08