Blood Pressure Variability in Acute Ischemic Stroke

NCT01915862 | Completed DMC

• 1 other identifier: AUTH-A7399-1862013
• Study Type: observational
• Target: 353
• Locations: 1 country
• Sites: 3

Brief Summary

The purpose of this study is the evaluation and comparison of blood pressure variability indices and ambulatory arterial stiffness index obtained by ambulatory blood pressure monitoring as prognostic indicators in the functional outcome of acute ischemic stroke.

Conditions

Ischemic Stroke

Keywords

Acute ischemic stroke; Blood pressure variability; Ambulatory arterial stiffness index; Ambulatory blood pressure monitoring; Outcome

Outcome Measures

Primary Outcomes (1)

• Modified Rankin Scale Score (mRS)

  Description (score) * No symptoms at all (0) * No significant disability despite symptoms; able to carry out all usual duties and activities (1) * Slight disability; unable to carry out all previous activities, but able to look after own affairs without assistance (2) * Moderate disability; requiring some help, but able to walk without assistance (3) * Moderately severe disability; unable to walk without assistance and unable to attend to own bodily needs without assistance (4) * Severe disability; bedridden, incontinent and requiring constant nursing care and attention(5) * Dead (6)

  Three months (90 days)

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All consecutive patients admitted to Departments of Medicine of three University Hospitals (Thessaloniki, Larissa, Ioannina) with the diagnosis of acute ischemic stroke

You may qualify if:

• Acute ischemic stroke
• Admission within 24 after the onset of symptoms

You may not qualify if:

• Transient ischemic attack
• Intracerebral hemorrhage
• Subarachnoid hemorrhage
• Cerebral sinus venous thrombosis
• Stroke mimics
• Late admission (\>24 hours after stroke onset)

Sponsors & Collaborators

• Aristotle University Of Thessaloniki: lead
• A & D Company Limited: collaborator

Study Sites (3)

Second Department of Internal Medicine, Medical School, University of Ioannina, University Hospital of Ioannina

Ioannina, 45110, Greece

Location

Department of Medicine, Medical School, University of Thessaly, University Hospital of Larissa

Larissa, 41110, Greece

Location

First Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, AHEPA University Hospital

Thessaloniki, 54636, Greece

Location

Related Publications (5)

• Kakaletsis N, Ntaios G, Milionis H, Haidich AB, Makaritsis K, Savopoulos C, Berge E, Hatzitolios AI. Prognostic value of 24-h ABPM in acute ischemic stroke for short-, medium-, and long-term outcome: a systematic review and meta-analysis. Int J Stroke. 2015 Oct;10(7):1000-7. doi: 10.1111/ijs.12609. Epub 2015 Aug 18.

  PMID: 26283262 BACKGROUND

• Kakaletsis N, Ntaios G, Milionis H, Karagiannaki A, Chouvarda I, Dourliou V, Chytas A, Hatzitolios AI, Savopoulos C. Prognostic significance of 24-h blood pressure and variability indices in the outcome of acute ischaemic stroke. Intern Med J. 2023 Jul;53(7):1137-1146. doi: 10.1111/imj.15834. Epub 2022 Sep 12.

  PMID: 35666577 RESULT

• Kakaletsis N, Ntaios G, Milionis H, Protogerou AD, Karagiannaki A, Chouvarda I, Dourliou V, Ladakis I, Kaiafa G, Daios S, Doumas M, Savopoulos C. Time of blood pressure in target range in acute ischemic stroke. J Hypertens. 2023 Feb 1;41(2):303-309. doi: 10.1097/HJH.0000000000003331. Epub 2022 Nov 25.

  PMID: 36583356 RESULT

• Kakaletsis N, Ntaios G, Milionis H, Karagiannaki A, Chouvarda I, Dourliou V, Ladakis I, Kaiafa G, Vemmos K, Savopoulos C. Midday Dipping and Circadian Blood Pressure Patterns in Acute Ischemic Stroke. J Clin Med. 2023 Jul 21;12(14):4816. doi: 10.3390/jcm12144816.

  PMID: 37510931 RESULT

• Karagiannaki A, Kakaletsis N, Chouvarda I, Dourliou V, Milionis H, Savopoulos C, Ntaios G. Association between antihypertensive treatment, blood pressure variability, and stroke severity and outcomes in acute ischemic stroke. J Clin Neurosci. 2024 Jul;125:51-58. doi: 10.1016/j.jocn.2024.05.014. Epub 2024 May 15.

  PMID: 38754240 RESULT

MeSH Terms

Conditions

Ischemic Stroke

Condition Hierarchy (Ancestors)

Stroke; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases

Study Officials

• Apostolos I. Hatzitolios, MD, PhD

  Aristotle University of Thessaloniki, AHEPA University Hospital

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 3 Months
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: MD, MSc, Resident in Internal Medicine, AHEPA University Hospital

Study Record Dates

• First Submitted: August 1, 2013
• First Posted: August 5, 2013
• Study Start: August 1, 2013
• Primary Completion: May 1, 2018
• Study Completion: December 1, 2018
• Last Updated: May 20, 2024

Record last verified: 2024-05

Locations

GR (3)