Tumor and Development (TED)
TED
Identification of Patients/Families With a Paediatric Tumor and One or More Developmental Abnormalities - Characterization of New Tumor Predisposition Syndromes and Study Their Molecular Basis
2 other identifiers
observational
998
1 country
1
Brief Summary
The overall project goal is to build a database of childhood cancers associated with developmental anomalies; it aims at identifying new syndromes of genetic predisposition and at enabling the further study of their molecular basis.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Jun 2013
Longer than P75 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
June 1, 2013
CompletedFirst Submitted
Initial submission to the registry
August 2, 2013
CompletedFirst Posted
Study publicly available on registry
August 5, 2013
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2022
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2022
CompletedFebruary 13, 2026
February 1, 2026
9.5 years
August 2, 2013
February 11, 2026
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Registration of developmental abnormalities in pediatric patients with cancer retrospectively and prospectively for a period of three years on a nationwide scale
Day 0
Secondary Outcomes (2)
to record tumoral pathologies in known contexts of cancer predisposition
Day 0
to record tumoral pathologies occurring in association with one or more developmental anomaly, these associations might have been already described or not
Day 0
Study Arms (1)
Patient having a cancer and abnormal development
Patient having developed a cancerous pathology and presenting one or several anomalies of the development.
Interventions
all tumor pathology associated with anomaly of development
Eligibility Criteria
Patient having developed a cancerous pathology and presenting one or several anomalies of the development.
You may qualify if:
- \- Patient who developed before the age of 18 years a solid tumour or a malignant or borderline hemopathy.
- AND
- Presenting one or several abnormality (ies) of the development provided it is not related to the treatment and\\or to the disease among:
- organ malformation, familial or not
- neuro-sensory deficit, familial or not
- delay of psychomotor acquisitions
- epilepsy (not as a sequelae of the tumour)
- disorder of growth and\\or weight and\\or of the cranial perimeter
- congenital, sporadic and\\or familial endocrine or metabolic disease
- dysmorphy
- Informed consent of patient and parents to this study OR
- tumour predisposition syndrome or developmental abnormality in a familial context, the molecular basis might have been already identified or not
You may not qualify if:
- absence of malignancy in the index case
- lack of developmental anomalies in the index case or in a related first degree
- abnormal development recognized as acquired (traumatic, toxic, infectious, perinatal…)
- age \> 18 years at diagnosis of the tumor
- Lack of informed consent of the legal representatives
- The familial aggregations of cancer without developmental disease are not included in this study.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Hôpital Necker Enfants Malades
Paris, 75015, France
Related Publications (1)
Semeraro M, Fouquet C, Vial Y, Amiel J, Galmiche L, Cretolle C, Blanc T, Jolaine V, Garcelon N, Entz-Werle N, Pellier I, Verite C, Sophie Taque, Coulomb A, Petit A, Corradini N, Bouazza N, Lacour B, Clavel J, Brugieres L, Bourdeaut F, Sarnacki S; members of the TED Consortium. Pediatric Tumors and Developmental Anomalies: A French Nationwide Cohort Study. J Pediatr. 2023 Aug;259:113451. doi: 10.1016/j.jpeds.2023.113451. Epub 2023 May 9.
PMID: 37169337RESULT
MeSH Terms
Conditions
Interventions
Intervention Hierarchy (Ancestors)
Study Officials
- STUDY DIRECTOR
Sabine SARNACKI, MD, PhD
Groupement Hospitalier Necker 149 rue de Sèvres 75015 PARIS France
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- OTHER
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
August 2, 2013
First Posted
August 5, 2013
Study Start
June 1, 2013
Primary Completion
December 1, 2022
Study Completion
December 1, 2022
Last Updated
February 13, 2026
Record last verified: 2026-02