The Effect of Ischemic Pre-Conditioning on the Rate of Recovery Following Exercise-Induced Muscle Damage

NCT01907841 | Completed

• 1 other identifier: IPCEIMD001
• Study Type: interventional
• Target: 24
• Locations: 1 country
• Sites: 1

Brief Summary

Strenuous exercise or exercise involving eccentric muscle contractions can lead to muscle damage and changes in muscle function; this is known as exercise-induced muscle damage (EIMD). It is known that brief, repeated periods of ischemia followed by reperfusion, known as Ischemic Preconditioning (IPC) cause a delay in cell injury in cardiac muscle as well as in various other organs. Therefore the purpose of this study is to:

1. 1.Quantify the use of IPC in recovery following EIMD.
2. 2.Identify any effect of IPC during recovery on muscle function

Conditions

Exercise-induced Muscle Damage

Keywords

Investigate IPC on EIMD

Outcome Measures

Primary Outcomes (1)

• Change from baseline in maximal voluntary contraction

  Isometric MVC of the participants' dominant knee extensors was assessed using a strain gauge. MVCs were performed for 3 s with a 60 s rest between each repetition. The change in MVC will be determined 24, 48 and 72 hours following pre exercise conditions.

  pre exercise, 24 hours post, 48 hours post and 72 hours post exercise

Secondary Outcomes (4)

• Change from baseline in Creatine kinase

  pre exercise, 24 hours post, 48 hours post and 72 hours post exercise

• Change from baseline in Limb girth

  pre exercise, 24 hours post, 48 hours post and 72 hours post exercise

• Chnage from baseline in Vertical jump

  pre exercise, 24 hours post, 48 hours post and 72 hours post exercise

• Change from baseline in Muscle soreness

  pre exercise, 24 hours post, 48 hours post and 72 hours post exercise

Study Arms (2)

Ischemic Preconditioning

EXPERIMENTAL

IPC (4 x 5 minute cycles @ 220 mmHg) with 5 min reperfusion between trials.

Other: Ischemic Preconditioning

Ischemic Preconditioning Placebo

PLACEBO COMPARATOR

Placebo (4 x 5 minute cycles @ 20mmHg) with 5 minutes between each cycle

Other: Ischemic Preconditioning

Interventions

Ischemic Preconditioning OTHER

Ischemic Preconditioning; Ischemic Preconditioning Placebo

Eligibility Criteria

• Age: 18 Years - 45 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Physically Active Males

You may not qualify if:

• Muscular skeletal disorders

Sponsors & Collaborators

• St Mary's University College: lead

Study Sites (1)

St Marys Umiversity College

London, TW1 4SX, United Kingdom

Location

MeSH Terms

Interventions

Ischemic Preconditioning

Intervention Hierarchy (Ancestors)

Therapeutics; Investigative Techniques

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Senior Lecturer Exercise Physiology

Study Record Dates

• First Submitted: July 15, 2013
• First Posted: July 25, 2013
• Study Start: July 1, 2013
• Primary Completion: November 1, 2013
• Study Completion: November 1, 2013
• Last Updated: March 6, 2014

Record last verified: 2014-03

Locations

GB (1)